Introduction
In order to supply the required nutrients to the various parts of the body, the heart pumps blood. Blood pressure is the pressure applied by the blood on the walls of the vessels carrying blood.1,2,3
The higher value of blood pressure than normal is regarded as hypertension. This happens due to numerous reasons, and there are various symptoms associated with hypertension, like headache of extreme intensity, pain in the chest region, vomiting, dizziness, confusion, vision gets blurred vision, ear buzzing, and heartbeat gets abnormal.4,5
Hypertension gets intensified, and symptoms associated with it become worse with many kinds of viral infections. Adenovirus is a kind of disease-causing agent which is one of the major culprits of the issues related to the heart.
Adenovirus infects people of all ages and spreads by means of respiratory droplets and/or contact (direct or indirect). This is the reason why it is mainly found in crowded places.6
Adenovirus is considered cured when the defence system of the body fights against it. That is why the patients with weak immune systems are largely attacked by it, and it mainly affects the respiratory system, the system related to digestion, and the kidneys.7,8
The heart is also impacted by adenovirus, which leads to many health problems related to the heart, and adenovirus’s effect on blood pressure is one of the primary effects among all.9
How does adenovirus cause the symptoms among hypertensive patients?
Adenovirus influences the symptoms of hypertension mainly in two ways, viz., either by showing
direct impact on hypertension or by impacting the end sites at which symptoms are observed.
Adenovirus impacting the heart
There is evidence that adenovirus has caused hypertension directly, as adenovirus causes inflammation of the inner lining of the heart. When this condition persists for a long period of time, it causes dilated cardiomyopathy (DCM).
DCM is a medical condition in which the walls of the heart muscle become weaker and the wall becomes way thinner than normal.
This leads the chamber to get bigger in size, which pumps blood to the entire body. There are studies which vindicate the fact that there are special sites (medically called receptors) present in the body which allow the adenovirus to get attached and exert its action at the site.
This is certainly responsible for making the patient suffer from hypertension in normal cases, and in individuals with already increased blood pressure, i.e., hypertension, the condition degrades further.9, 10, 11
When does adenovirus mimic the natural molecule?
There are many kinds of complex processes in the human body which need ions to be functional. Heart muscles contract and relax to pump blood, and this action of heart muscles is supported by special kinds of ions (an important fact to know, this is the reason why physicians advise decreasing the salt intake).
Ions move through the cell wall via a specific sort of entry/exit gate. Adenovirus is found to act in a typical manner where it generates a particular kind of molecule that directly affects the ion entry/exit gates and changes their normal function.
These amendments render fluctuations in the normal pumping pattern of the heart or rhythm, which eventually worsen the existing hypertension condition and might lead the patient to death as well.12
When are the kidneys under attack?
Kidney-related issues associated with adenovirus make the hypertensive patient suffer even worse with symptoms than a normal hypertensive one.
Adenovirus can cause inflammation at the site of the kidney, which is responsible for the filtration of the blood. Once this happens, extensive retention of ions is inevitable, especially the sodium ions. This further leads the body to have an overloaded fluid as well.
Due to this, one of the most important mechanisms to control hypertension gets impacted, and leads the hypertension to become worse, so do the symptoms.8,13
Vessels that carry blood become victims
As you have understood by now, hypertension takes place due to many reasons, and out of those reasons can be the inflammation of the muscles of the blood carrying vessels due to a weak immune system.
In these sorts of immunocompromised cases, adenovirus attacks the patients and aggravates hypertension. This intensified hypertension shows far worse symptoms. This can also initiate the pain sensations of extreme intensity in the chest region.14
Adenovirus affects the respiratory system
Respiratory issues associated with adenovirus make hypertension and its symptoms even worse.
At times, breathing issues associated with hypertension are found in the majority of patients. Lungs get the blood from typical kinds of vessels, and blood pressure increases in that which renders the patient's condition just mentioned before.
Adenovirus infection in such cases can be life-threatening as it amplifies the breathing issues, due to the fact that the respiratory tract is one of its primary action sites for adenovirus to act.
This may act in many ways, like adenovirus can cause the inflammation of the innermost lining of the lungs, which is enough to cause difficulty in breathing. This can also cause the respiratory system to fail completely in healthy persons.
The hypertensive patients, who suffer from short breath already, can have breathing issues of extreme levels when they get attacked by adenovirus.6,7
The impact of adenovirus is seen in the eyes as well
Hypertensive patients have reported being victims of blurred vision. Eyes feel heavier to the patient as blood pressure surges in the eyes’ blood vessels. These vessels then push the tissues in the eyes.
This stage is of extreme severity on its own, but if adenovirus attacks an already impacted patient with this condition can hit the maximum limit of torture. Adenovirus can infect the eyes, and a pink to red colour might be evident in the patient’s eyes.
This can intensify the high blood pressure’s effect many times, and it is important to know that any leakage of the fluid in the eyes due to increased pressure might be a culprit of eyesight changes.15
For hypertensive patients, adenovirus causes a headache
Patients with hypertension might feel confusion, vomiting, difficulty in standing, and headache as the basic symptoms linked with hypertension. This is because of the sudden increase in the blood supply to the brain.
There are a few reasons for this condition to occur, viz., issues related to the kidneys related issues are a very common reason for this to take place.
Another interesting reason to know is that a few disorders related to immunity occur when the body’s own defence mechanism works against the body itself. When this type of disorder is treated, medicines are given to suppress the immune function a bit, and this is a definite invitation to disease-causing agents like adenovirus to attack the patient’s body.
Adenovirus exacerbates the symptoms mentioned earlier, which arise from the increased blood pressure in the brain. This might cause swelling in the brain, too. The condition, even without adenovirus, can be fatal; with adenovirus, it might be extremely painful till the patient’s demise.16
Adenovirus is harsh on the ears, too
A buzzing sound is heard by a patient suffering from hypertension, and this is mainly common among patients whose assessment of blood pressure shows the systolic value as over 140 mmHg and the diastolic value as over 90 mmHg.
When a patient with the condition just discussed comes under the adenovirus attack, then the middle ear section becomes prone to other kinds of infections, and the condition becomes worse.
It happens because the tube which connects the ear and mouth incurs the impact by adenovirus, which allows other bacteria to affect the area of the middle ear.17
Summary
Blood circulates in the body to perform many functions. When it is pumped by the heart, it exerts some sort of pressure on the walls of the vessels which carry it. The condition in which that pressure exceeds the normal value is called hypertension.
An agent that causes diseases, named adenovirus, is dealt with by the immune system of the body and cured on its own this way. However, in people with weak immunity, it shows its maximum effect.
There are many sorts of symptoms that are associated with hypertension, like, headache, vision issues, pain in chest pain, ear buzzing, and heartbeat becomes abnormal heartbeat. Adenovirus can exacerbate the symptoms associated with hypertension.
Adenovirus attacks the heart directly and causes changes in the size of the heart; it generates a molecule which impersonates a naturally existing molecule and affects the blood-pumping pattern of the heart, and it attacks the kidneys, whereby more ions get retained in the body. All these affect the blood pressure directly, due to which symptoms intensify.
It also shows its impact on the sites at which symptoms of hypertension are observed, and aggravates them. Its profound effect on the brains of hypertensive patients has been found.
Since the respiratory system is one of the most attacked body systems by adenovirus, it also gets amplified blood pressure-related symptoms. Eyes, ears, and brain are not exempt from the matter under discussion.
References
- www.heart.org [Internet]. [cited 2024 Jun 19]. What is high blood pressure? Available from: https://www.heart.org/en/health-topics/high-blood-pressure/the-facts-about-high-blood-pressure/what-is-high-blood-pressure
- nhs.uk [Internet]. 2017 [cited 2024 Jun 19]. High blood pressure (Hypertension). Available from: https://www.nhs.uk/conditions/high-blood-pressure-hypertension/
- Hypertension [Internet]. [cited 2024 Jun 19]. Available from: https://www.who.int/news-room/fact-sheets/detail/hypertension
- High blood pressure - symptoms | nhlbi, nih [Internet]. 2024 [cited 2024 Jun 19]. Available from: https://www.nhlbi.nih.gov/health/high-blood-pressure/symptoms
- British Heart Foundation [Internet]. [cited 2024 Jun 19]. High blood pressure - symptoms and treatment. Available from: https://www.bhf.org.uk/informationsupport/risk-factors/high-blood-pressure/symptoms-and-treatment
- Usman N, Suarez M. Adenoviruses. In: StatPearls [Internet] [Internet]. StatPearls Publishing; 2023 [cited 2024 Jun 19]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559072/
- Adenovirus infection [Internet]. Epidemiology. [cited 2024 Jun 19]. Available from: https://www.vdh.virginia.gov/epidemiology/epidemiology-fact-sheets/adenovirus-infection/
- Savedchuk S, Raslan R, Nystrom S, Sparks MA. Emerging viral infections and the potential impact on hypertension, cardiovascular disease, and kidney disease. Circulation Research [Internet]. 2022 May 13 [cited 2024 Jun 19];130(10):1618–41. Available from: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.320873
- Towbin JA, Bowles NE. Diagnosis and treatment of myocarditis: the role of adenovirus infection in cardiomyopathy and heart failure. In: Matsumori A, editor. Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms [Internet]. Boston, MA: Springer US; 2003 [cited 2024 Jun 19]. p. 341–55. Available from: https://doi.org/10.1007/978-1-4419-9264-2_26
- Kaur T, Mishra B, Saikia UN, Sharma M, Bahl A, Ratho RK. Expression of coxsackievirus and adenovirus receptor and its cellular localization in myocardial tissues of dilated cardiomyopathy. Experimental & Clinical Cardiology [Internet]. 2012 Winter [cited 2024 Jun 19];17(4):183. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627271/
- Pauschinger M, Bowles NE, Fuentes-Garcia FJ, Pham V, Kühl U, Schwimmbeck PL, et al. Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. Circulation [Internet]. 1999 Mar 16 [cited 2024 Jun 19];99(10):1348–54. Available from: https://www.ahajournals.org/doi/10.1161/01.CIR.99.10.1348
- Padget RL, Zeitz MJ, Blair GA, Wu X, North MD, Tanenbaum MT, et al. Acute adenoviral infection elicits an arrhythmogenic substrate prior to myocarditis. Circulation Research [Internet]. 2024 Mar 29 [cited 2024 Jun 19];134(7):892–912. Available from: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322437
- Ihm CG. Hypertension in chronic glomerulonephritis. Electrolytes & Blood Pressure : E & BP [Internet]. 2015 Dec [cited 2024 Jun 19];13(2):41. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737660/
- Zhang Z, Zhao L, Zhou X, Meng X, Zhou X. Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets. Frontiers in Immunology [Internet]. 2022 [cited 2024 Jun 19];13. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871625/
- Hoffman J. Adenovirus: ocular manifestations. Community Eye Health [Internet]. 2020 [cited 2024 Jun 19];33(108):73. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205173/
- Potter T, Agarwal A, Schaefer TJ. Hypertensive encephalopathy. In: StatPearls [Internet] [Internet]. StatPearls Publishing; 2024 [cited 2024 Jun 19]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554499/
- Murrah KA, Turner RL, Pang B, Perez AC, Reimche JL, King LB, et al. Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis [Internet]. 2015 Mar [cited 2024 Jun 19];73(2):1–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344901/

