Role of oestrogen
Oestrogen is a hormone produced in the adrenal glands, skin, liver, bones and ovaries. This hormone plays an important part in various bodily functions, including bone development. It also facilitates the cognitive part of the brain, cardiovascular system and lipid metabolism. Oestrogen has a significant role in the female reproductive system. It aids in ovarian function and menstruation. Oestrogen helps your body during pregnancy and can also be blamed for mood changes.1
The female body produces four different types:
- Estrone E1: Estrone is a weak estrogen that releases during or after menopause. It is produced in the ovaries, placenta, and part of body fat.
- Estradiol E2: Estradiol is the active estrogen that is involved in menstruation.2
- Estriol E3: Estriol is also a weak estrogen that is produced during the early stage of pregnancy.
- Estetrol E4: Estetrol is produced in the liver of the fetus during pregnancy.3
High oestrogen levels
An increase in oestrogen levels causes a disturbance in normal body functions; this condition is also called oestrogen dominance. It can cause several diseases and may affect fertility in both men and women.
Causes of high oestrogen levels
Oestrogen levels increase in the body due to various reasons. One of the most common causes of oestrogen increase is an imbalance between the oestrogen and progesterone level, problems in oestrogen metabolism or any disease condition.
Let us see some examples:
Diseases: Many women experience the condition of PCOS (Poly Cystic Ovary Syndrome), which may be a symptom of increased oestrogen levels. Liver diseases, endometriosis and breast and ovarian cancers can be caused by an increased oestrogen level and may aggravate the condition.
Environment: Chemicals like Bisphenol A and Phthalate are found in daily use products, including soap, shampoo, and plastics which can cause hormonal imbalance.
Diet: Processed food and food low in fibre can disrupt the normal concentration of oestrogen levels. Alcohol intake affects the metabolism of oestrogen.
Medication: Contraceptives and hormone therapy can increase the oestrogen level in the body.
Stress: Stress is the main factor that can cause a hormonal imbalance in the body. 4,5
Can I get pregnant with high oestrogen levels?
Oestrogen is the hormone that is responsible for preparing your body for pregnancy. There is a chance that one can get pregnant with high oestrogen levels. However, to complete your pregnancy successfully, you must avoid food that causes hormonal imbalance. Adapting a healthy diet and adding supplements usually helps with conceiving. Consult your gynaecologist for proper guidance. 6
Symptoms of high oestrogen
Women (People assigned female at birth)
- Irregular or painful period
- Weight gain
- Thyroid dysfunction
- Fatigue
- Headache
- Depression
- Irritability
- Breast tenderness
- Bloating
Men (People assigned male at birth)
- Insomnia
- Depression
- Low libido
- Erectile dysfunction
- Increase fat tissue7
Diagnosis of high oestrogen levels
Oestrogen levels can be determined with a simple blood or 24-hour urine test. With guidance from a doctor, oestrogen can also be determined by a saliva test. Doctors recommend oestrogen tests if they have any problem related to hormonal imbalances like difficulty in conceiving, especially in pregnancy, where a diagnosis of estrogen level is essential to avoid any risk. The method of diagnosis is recommended by a professional after discussing the patient’s medical history.8
Lowering oestrogen levels
The first step in the management of high oestrogen levels is to consult with a doctor who helps to identify the root cause and prescribe the regimen according to the individual requirement. Making positive changes in lifestyle and proper medication helps to lower the oestrogen level.
Medications
The doctor can prescribe the medication according to the cause of the high oestrogen level and the purpose of the treatment. For e.g
- Oestrogen Blocking drugs such as Aromatase inhibitors, gonadotropin-releasing hormone agonists, and Selective Oestrogen Receptor modulators (SERMs) are used to block the release of estrogen.
- Hormone-regulating supplements and Vitamin supplements such as B6, zinc and magnesium can regulate hormonal imbalances.
Lifestyle
Making some positive changes in lifestyle can help to maintain the desired oestrogen level.
- Try to avoid processed food and eat healthy or organic foods which provide nutrients.
- Exercise daily to reduce the amount of fat in the body.
- Manage stress through meditation or trying to get close to nature.
- Avoid exposure to chemicals that disturb oestrogen levels. 9
Fertility
Fertility is the ability of an individual to conceive naturally. Oestrogen is very important for a couple who wants to get pregnant: it helps to develop the uterine wall to sustain the pregnancy in women and the production of sperm in men. Balanced levels of oestrogen in the body increase the chances of a healthy pregnancy.
Other hormones that can affect fertility
Hormonal imbalance affects the normal function of the body and also decreases the chances for a couple to conceive naturally.
Low oestrogen
A low amount of oestrogen levels can affect fertility in both men and women. In men, sperm count can decrease due to low production of oestrogen and women's body are not able to release eggs during ovulation; that's why it is prescribed for women who choose In Vitro Fertilisation (IVF).
Testosterone
Low levels of testosterone produce erectile dysfunction and decrease the production of sperm: this condition is called hypogonadism. Testosterone helps to increase libido in women. It contributes to the sexual desire of both men and women.
Androgens
Androgen is a hormone related to the male hormone, testosterone which helps to develop the parts of the body in men. This helps in reproduction, and women's bodies can also produce androgens hormone in a small amount. Low levels of androgens in both men and women cause difficulty in fertilization.
How to improve fertility
To improve the chances of fertility, consult with a fertility specialist who can perform the necessary diagnostic procedure to identify the cause of infertility and prescribe treatment. Avoid food that causes hormonal imbalance and take on a diet that helps to achieve essential nutrients. Take prenatal vitamins, including B6, Zinc, and Magnesium. Try performing fertility exercises and Yoga as well as remembering to remain hydrated. Most importantly, stay positive and do what makes you happy.10,11
Summary
You can get pregnant with a high oestrogen level, but to sustain pregnancy and a healthy baby, you must maintain a balanced hormonal level. Disturbance in hormones can affect the chances of fertility in people. To avoid this situation, one needs to adopt a healthy lifestyle and diet that fulfils the requirements of nutrients. Take supplements and exercise daily to get a healthy body.
References
- Delgado BJ, Lopez-Ojeda W. Estrogen. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2022 Oct 23]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK538260/
- Patel S, Homaei A, Raju AB, Meher BR. Estrogen: The necessary evil for human health, and ways to tame it. Biomedicine & Pharmacotherapy [Internet]. 2018 Jun 1 [cited 2022 Aug 19];102:403–11. Available from: https://www.sciencedirect.com/science/article/pii/S0753332217353246
- Holinka CF, Diczfalusy E, Coelingh Bennink HJT. Estetrol: A unique steroid in human pregnancy. The Journal of Steroid Biochemistry and Molecular Biology [Internet]. 2008 May 1 [cited 2022 Aug 19];110(1):138–43. Available from: https://www.sciencedirect.com/science/article/pii/S0960076008000794
- Kloss JD, Perlis ML, Zamzow JA, Culnan EJ, Gracia CR. Sleep, sleep disturbance, and fertility in women. Sleep Medicine Reviews [Internet]. 2015 Aug 1 [cited 2022 Aug 19];22:78–87. Available from: https://www.sciencedirect.com/science/article/pii/S108707921400104X
- Madigan MP, Troisi R, Potischman N, Dorgan JF, Brinton LA, Hoover RN. Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women (United States). Cancer Causes Control [Internet]. 1998 Mar 1 [cited 2022 Aug 19];9(2):199–207. Available from: https://doi.org/10.1023/A:1008838412
- Estrogen maintains pregnancy and triggers fetal maturation [Internet]. [cited 2022 Aug 19]. Available from: https://www.sciencedaily.com/releases/1997/03/970321141042.htm
- Estrogen dominance - whole health library [Internet]. [cited 2022 Aug 19]. Available from: https://www.va.gov/WHOLEHEALTHLIBRARY/tools/estrogen-dominance.asp
- Estrogens | LabCorp [Internet]. [cited 2022 Aug 19]. Available from: https://www.labcorp.com/help/patient-test-info/estrogens
- Nazni P. Association of western diet & lifestyle with decreased fertility. Indian J Med Res [Internet]. 2014 Nov [cited 2022 Aug 19];140(Suppl 1): S78–81. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345758/
- Healy DL, Trounson AO, Andersen AN. Female infertility: causes and treatment. Lancet. 1994 Jun 18;343(8912):1539–44
- Sengupta P, Dutta S. Hormones in male reproduction and fertility. Asian Pac J Reprod [Internet]. 2019 [cited 2022 Aug 19];8(5):187. Available from: http://www.apjr.net/text.asp?2019/8/5/187/268671