Complications Of Balantidiasis
Published on: November 2, 2024
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    Velamala Sai Sudha

    Doctor of Pharmacy - Dayananda Sagar College of Pharmacy, Bangalore, India

What is balantidiasis? 

Balantidiasis is an uncommon intestinal infection caused by the bacterium Balantidium coli.

Balantidium coli is found all over the world, specifically in countries such as Brazil, New Guinea, the Pacific Islands, South America, and central Asia, in countries with inadequate environmental and sanitary conditions.

Balantidium coli is the biggest and only ciliate protozoan that can infect humans. Pigs are the main reservoir hosts. The parasite can be transmitted directly to humans through contact with pig feces or indirectly through the consumption of contaminated water.

What are the symptoms of balantidiasis?

In most instances, blantidiasis remains asymptomatic. However, when it invades the intestinal mucosa, it may result in balantidial dysentery. Acute illness may manifest in certain individuals, leading to significantly elevated body temperatures, abdominal pain, vomiting, and diarrhoea with blood.

It may also lead to extraintestinal infections of the liver, lungs, peritoneum, and genitourinary tract.

Complications

Intestinal complications: In severe cases, the parasite can invade the intestinal wall, resulting in inflammation and ulceration. If left untreated, this may lead to chronic inflammation, nutrient malabsorption, and weight loss.

Intestinal perforation and peritonitis represent the predominant causes of mortality linked to balantidiasis.

  • Intestinal perforation: Intestinal perforation, characterized as a disruption in the continuity of the bowel wall, necessitates emergency medical attention. Almost all patients experience some degree of abdominal pain, which is typically accompanied by nausea, vomiting, reduced bowel function, or fever. A CT scan of the abdomen and pelvis is the best test for accurately spotting any perforation. In pediatric patients, the preferred primary diagnostic method is ultrasound due to its simplicity and absence of radiation exposure. As a treatment, some cases require surgery. However, all cases should be assessed by a surgeon. The initial treatment includes bowel rest, intravenous fluid administration, intravenous broad-spectrum antibiotics, and routine abdominal examinations.6
  • Peritonitis: Peritonitis is the inflammation of the peritoneum, the tissue that lines the interior of the abdominal cavity. Infection in the peritoneum is particularly concerning as it may impact the abdominal organs and has the potential to spread to the bloodstream, leading to a life-threatening end of infection named sepsis. Signs and symptoms are mild to severe abdominal pain, dehydration, swollen abdomen, temporarily paralyzed bowels, nausea and vomiting, fever, and fatigue. Physical examination and blood tests to check for evidence of infection are required. Broad-spectrum antibiotics serve as the treatment, and in certain cases, emergency surgery may be necessary for repair. Peritonitis can arise quite abruptly, and it is essential to respond promptly when it occurs.7
  • Systemic complications: The parasite has the capability to infiltrate the bloodstream and disseminate to various organs, resulting in conditions such as hepatic abscess or pulmonary infections. These systemic complications necessitate immediate medical intervention and treatment.

How is balantidiasis diagnosed?

The diagnosis of bilantidiasis can be challenging, as other conditions affecting the bowel may exhibit similar symptoms.

Treatment

The treatment of balantidiasis typically involves the administration of antibiotics, and it is essential to complete the full course of treatment to ensure the eradication of the infection.

Maintaining good hygiene practices, such as washing hands before eating and consuming clean water, can aid in preventing the spread of the disease.

Summary

Balantidiasis is a treatable condition resulting from the ingestion of the intestinal parasite, Balantidium coli, via food or water contaminated by human or animal feces.

People who have this infection usually don’t show any signs or symptoms if it’s mild. However, they may experience symptoms such as diarrhea, abdominal pain, and, in severe cases, the formation of a perforation in the colon.

In severe cases, the infection may disseminate to other organs, resulting in more significant complications.

Poor nutrition, a weakened immune system, or other health issues can make someone more susceptible to worse symptoms of Balantidiasis disease.

Balantidiasis can be diagnosed through laboratory analysis of the stool.

Treatment for balantidiasis generally involves the administration of antibiotics, which can effectively eradicate the parasite and alleviate the associated symptoms.

References

  1. Balantidiasis [Internet]. 2019 [cited 2024 Jul 30]. Available from: https://www.cdc.gov/dpdx/balantidiasis/index.html
  2. Almaw A, Berhan A, Solomon Y, Malkamu B, Eyayu T, Workineh L, et al. Balantidium coli; rare and accidental finding in the urine of pregnant woman: case report. Int Med Case Rep J [Internet]. 2022 Mar 22 [cited 2024 Jul 30];15:105–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957295/
  3. Balantidiasis - symptoms, causes, treatment | nord [Internet]. [cited 2024 Jul 30]. Available from: https://rarediseases.org/rare-diseases/balantidiasis/
  4. da Silva RKM, Dib LV, Amendoeira MR, Class CC, Pinheiro JL, Fonseca ABM, et al. Balantidiasis in humans: A systematic review and meta-analysis. Acta Tropica [Internet]. 2021 Nov 1 [cited 2024 Jul 30];223:106069. Available from: https://www.sciencedirect.com/science/article/pii/S0001706X21002485
  5. Balantidiasis - symptoms, causes, diagnosis, and treatment of balantidium coli infection [Internet]. Infection Cycle. 2023 [cited 2024 Jul 30]. Available from: https://infectioncycle.com/articles/balantidiasis-symptoms-causes-diagnosis-and-treatment-of-balantidium-coli-infection
  6. Hafner J, Tuma F, Hoilat GJ, Marar O. Intestinal perforation. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Jul 30]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK538191/
  7. nhs.uk [Internet]. 2017 [cited 2024 Jul 30]. Peritonitis. Available from: https://www.nhs.uk/conditions/peritonitis/
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Mihaela Ragabeja

Bachelor’s Degree in Medicine, Ovidius University, Romania

NHS doctor, United Kingdom

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