Grape Seed And Diabetes Management

  • Mercy ChepkemoiBachelor in Medicine and Bachelor in Surgery (MBChB), Moi University

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Grape seeds, often discarded without a second thought, hold within them a treasure trove of health-promoting compounds. These tiny seeds, nestled within the succulent flesh of grapes, have been explored for their potent antioxidant properties and potential to boost overall health and well-being.

Diabetes, a chronic metabolic disorder characterised by elevated blood sugar levels, affects millions worldwide and requires diligent management to prevent complications. While traditional treatments such as medication and lifestyle modifications remain cornerstones in diabetes management, new studies suggest that adding grape seed into the diet may help manage this condition better.

The link between grape seed and diabetes control lies in important natural compounds found in grape seeds, especially polyphenols. These compounds have been found to have strong effects against harmful substances in the body, reduce swelling, and regulate blood sugar, all of which are really important in the management of diabetes. By understanding how grape seeds affect diabetes, individuals may use them along with existing treatment strategies to improve their overall health outcomes.

Understanding Diabetes

Types of Diabetes

Diabetes is a chronic condition where the body fails to regulate sugar levels in the bloodstream, resulting in hyperglycemia, or high glucose levels in the blood.1 This can occur due to the body's inability to produce enough insulin or because the body's cells and tissues fail to respond properly to insulin, which is the hormone responsible for managing blood glucose levels.

There are three kinds of diabetes:

  • Type 1 diabetes: happens when the immune system destroys cells in the pancreas that make insulin. It often starts in childhood or early adulthood and is linked to genetic factors. 
  • Type 2 diabetes:  occurs when body tissues become resistant to insulin, even though there is enough insulin in the bloodstream. This leads to high blood sugar levels as the body cannot effectively use the sugar.
  • Gestational diabetes affects pregnant women after twenty weeks of gestation. Hormonal changes during pregnancy may induce insulin resistance, impairing blood sugar regulation.

Symptoms of diabetes 

Common symptoms include:

  • Increased thirst
  • Frequent urination
  • Excessive hunger
  • Unintentional weight loss
  • Other symptoms are fatigue, slow wound healing, blurry vision, and recurrent infections

Complications of diabetes

Poorly controlled diabetes leads to damage to small blood vessels supplying the kidney (nephropathy), eyes (retinopathy), and nerves(neuropathy).2 This may in the long run cause kidney failure, blindness and foot ulcers thereby reducing the quality of life. Diabetes can also increase the risk of hypertension, cardiovascular diseases and stroke. Regular monitoring of blood sugar levels and adherence to the treatment prescribed by a healthcare provider are essential to manage diabetes effectively.

Grape Seed and Its Nutritional Components

Grapes are small, round or oval berries that grow in clusters on vines and are among the most highly consumed fruits around the world. For a long time, grapes were appreciated only for their sap and leaves. However, recently, the health benefits of grape seeds have also been discovered. Grape seeds have been shown to contain not only Vitamins and minerals, but also polyphenols and antioxidants. Polyphenols are natural compounds found in plants and have antioxidant properties, which means they help protect cells from damage caused by harmful molecules called free radicals. They are known to provide an array of health benefits, such as decreasing inflammation and lowering the risk of certain diseases including diabetes.3

Mechanisms of Grape Seed in Diabetes Management

Impact on Insulin Sensitivity

Insulin resistance, a common issue in diabetes, often stems from the presence of free radicals that disrupt the insulin signalling process.5 Luckily, polyphenols found in grape seeds can counteract these harmful substances, reducing oxidative stress and aiding in better insulin sensitivity. In addition, polyphenols also play a protective role in maintaining the function of pancreatic cells responsible for insulin production.2

Effect on blood sugar control

Another notable benefit of grape seeds is their knack for regulating blood sugar levels, which is crucial for individuals managing diabetes. Studies have shown that grape seed extracts inhibit enzymes involved in breaking down carbohydrates into glucose during digestion.3 This slowdown helps prevent sudden spikes in blood glucose levels after meals, thereby improving overall glycemic control. This is especially beneficial in Type 2 diabetes management.

Effects on Diabetic Complications:

Managing diabetes is not just about controlling blood sugar; it's also about preventing complications. Grape seed polyphenols come to the rescue again, offering protection against diabetic nephropathy and retinopathy by exhibiting antioxidant defences and reducing oxidative stress. Moreover, their anti-inflammatory properties can alleviate the discomfort associated with diabetic neuropathy.

Whether incorporated into one's diet or taken as supplements, grape seeds can complement existing diabetes management strategies. However, it's essential to consult with a healthcare professional before making significant changes, especially for those on medication or with specific dietary restrictions.

In summary, the multifaceted benefits of grape seeds in managing diabetes, from improving insulin sensitivity to regulating blood sugar levels and mitigating complications, highlight their potential to promote overall health and well-being for individuals living with diabetes.

Practical Applications and Recommendations

Incorporating Grape Seed into Your Diet

One easy way to include grape seeds in your diet is by consuming whole grapes, as the seeds are typically found within the fruit. You can also find grape seed oil, which can be used in cooking or salad dressings. Another option is to purchase grape seed extract supplements, available in capsule or liquid form.

Supplement Options and Dosages

When opting for grape seed extract supplements, it's essential to choose high-quality products from reputable brands to ensure purity and potency. Dosages may vary depending on the specific supplement and individual health factors. However, a typical dosage ranges from 100 to 300 milligrams per day. It's advisable to start with a lower dosage and gradually increase it as required, under the guidance of a healthcare professional.

Potential Interactions with Medications

While grape seed extract is generally considered safe for most people, it's essential to be aware of potential interactions with medications. Grape seed extract may interact with blood thinners, anticoagulants, and antiplatelet medications, thereby increasing the risk of bleeding.4 It may also interact with some drugs metabolized by the liver. Therefore, if you're taking any medications, it's crucial to consult with your healthcare provider before starting grape seed supplements to avoid any adverse effects or interactions.

Incorporating grape seed into your diet or opting for supplements can be a simple yet effective way to reap the numerous health benefits they offer. However, it's important to do so cautiously and under the guidance of a healthcare professional, especially if you have any underlying health conditions or are taking medications. With the right approach, you can harness the power of grape seed to support your overall health and well-being.


Grape seeds offer great potential in the management of diabetes due to their rich content of antioxidants and polyphenols. These compounds help improve insulin sensitivity, regulate blood sugar levels, and reduce inflammation, which are crucial factors in diabetes management. Incorporating grape seeds into the diet or taking grape seed extract supplements may complement existing treatment strategies and contribute to better blood sugar control.

Key Points:

  • Antioxidants and Polyphenols: Grape seeds contain potent antioxidants and polyphenols that can help improve insulin sensitivity and regulate blood sugar levels.
  • Insulin Sensitivity: Studies suggest that grape seed extract may help enhance insulin sensitivity and reduce insulin resistance, which are important in managing type 2 diabetes.
  • Blood Sugar Regulation: The compounds found in grape seeds may aid in controlling blood sugar levels, potentially reducing the risk of diabetes-related complications.
  • Future Outlook: The future outlook for grape seed in diabetes management looks promising, with ongoing research exploring its potential benefits and mechanisms of action.


Are grape seeds good for diabetes?

Grape seeds contain antioxidants and polyphenols that have important roles in the management of diabetes. These bioactive compounds have been shown to improve insulin sensitivity, regulate blood sugar levels, and reduce inflammation, all of which are important factors in diabetes management. Including grape seeds in your diet or taking grape seed extract supplements may complement existing treatment strategies for diabetes.

What role do grape seeds play in diabetes?

Grape seeds are rich in polyphenols and antioxidants that help improve insulin sensitivity and regulate blood sugar levels. Consuming grape seeds, especially as part of a balanced diet, may have positive effects on diabetes management. However, it's essential to monitor portion sizes and overall carbohydrate intake, as grapes also contain natural sugars that can affect blood sugar levels.

Does grape seed help with insulin resistance?

Yes, grape seed may help improve insulin sensitivity and reduce insulin resistance, which are key factors in the development and management of type 2 diabetes. The antioxidants and polyphenols found in grape seeds have been shown to enhance insulin action and promote glucose uptake by cells, potentially improving overall blood sugar control.

Can I take grape seeds every day?

While grape seeds are generally considered safe for most people when used as directed, it's essential to consult with a healthcare professional before taking them daily, especially if you have any underlying health conditions or are taking medications. Some individuals may experience allergic reactions or interactions with certain medications, so it's important to discuss potential risks and benefits with your healthcare provider.

When is the best time to take grape seeds?

The best time to take grape seeds may vary depending on individual preferences and lifestyle factors. Some people prefer to take it with meals to aid in digestion and absorption, while others find it more convenient to take it separately. Ultimately, the most important factor is consistency in taking grape seeds as directed by your healthcare provider to maximize its potential benefits for diabetes management and overall health.


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  4. Mount Sinai Health System [Internet]. [cited 2024 Feb 10]. Grape seed information | mount sinai - new york. Available from:
  5. Mohammad A, Shahnaz T, Sorayya K. Effect of 8 weeks’ supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 2021 Jan 1 [cited 2024 Feb 9];15(1):197–203. Available from:
  6. Gupta M, Dey S, Marbaniang D, Pal P, Ray S, Mazumder B. Grape seed extract: having a potential health benefits. J Food Sci Technol. 2020 Apr;57(4):1205–15.
  7. Hurrle S, Hsu WH. The etiology of oxidative stress in insulin resistance. Biomed J [Internet]. 2017 Oct [cited 2024 Feb 9];40(5):257–62. Available from:
  8. Sochorova L, Prusova B, Jurikova T, Mlcek J, Adamkova A, Baron M, et al. The study of antioxidant components in grape seeds. Molecules [Internet]. 2020 Aug 15 [cited 2024 Feb 10];25(16):3736. Available from:
  9. National Institute of Diabetes and Digestive and Kidney Diseases [Internet]. [cited 2024 Feb 10]. What is diabetes? - niddk. Available from:
  10. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev [Internet]. 2009 [cited 2024 Feb 10];2(5):270–8. Available from:

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This content is purely informational and isn’t medical guidance. It shouldn’t replace professional medical counsel. Always consult your physician regarding treatment risks and benefits. See our editorial standards for more details.

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Mercy Chepkemoi

Bachelor in Medicine and Bachelor in Surgery (MBChB), Moi University

Mercy is a seasoned medical writer with a background in medicine. She is a global health enthusiast and has several years of experience in research, writing, and editing. In addition, she enjoys community health volunteer work.

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