Risk Factors for Blastomycosis Infection
Published on: June 28, 2025
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Bibek Rana Chhetri

Masters in Science- Biomedical Sciences, University of Chester, UK

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Philbeth Odidison

MSc Biotechnology & Bioengineering, University of Kent

You do realise that, in parts of the world, just stepping outside increases your risk of developing a potentially deadly fungal infection? The most typical symptoms of Blastomycosis include skin and respiratory issues, though it might affect other organs as well. If you do live in or are going to visit countries that record the greatest incidence of this type of fungus, the risk factors for Blastomycosis are something you should be very aware of.

In this regard, this paper aims to give a complete understanding of the risk factors linked to Blastomycosis infection, and upon which understanding, an individual should undertake interventions with the potential of reducing his or her chances of contracting the disease. This article seeks to identify the risk factors for infection-geographical, environmental, occupational, and personal conditions that increase risk, how the described factors influence incidences of Blastomycosis, and real-life recommendations on risk-provoking factors.

Risk factors

Geographic location

The infection, more than anything else, is geographically distributed. Areas with the greatest incidence of the disease include the Mississippi River valleys, Ohio River valleys, and the Great Lakes region. In these locations, specific environmental conditions prevail that promote the development of the fungus Blastomyces dermatitidis. The fungus usually occurs in damp soil and dead organic material like wood and leaves, making these places a very risky area of exposure.5

Occupational and recreational exposure

Any person whose job or hobby causes them to come into contact on a regular basis with soil and organic matter will increase their chances of being infected with Blastomycosis. For example, farmers, forestry workers, construction workers, landscapers-anyone who disturbs the soil-causes the spores to become airborne. People who participate in recreational activities such as hunting, camping, fishing, and hiking in endemic areas can also increase their risk of inhaling the spores.

Environmental conditions

There is a strong relationship between environmental factors to the prevalence of Blastomycosis. The fungus grows in organic-enriched soil and in humid and damp areas, generally near rivers, lakesides and swamps. Events that lead to soil disruption, for example, construction work or heavy rainfall, predispose to exposure.

Host factors

The risk of acquiring Blastomycosis is increased in people with a compromised immune system. Groups at an increased risk include patients who have HIV/AIDS, those receiving chemotherapy for neoplasm, patients who have had organ transplants, and those who have been on immunosuppressive drugs for years. History of pre-existing conditions regarding the lungs, including COPD, asthma, and previously treated tuberculosis, also presents people at an increased risk.1

Demographic factors

Demographic factors also bear some impact on the risk of Blastomycosis. The infection is more frequent in middle-aged adults but less common in children and in elderly individuals. There is a greater proportion of males as compared to females; again, this may be related to greater occupational and recreational risk. Racial and ethnic differences in susceptibility were forwarded by other studies, although much more work is necessary to define these differences.2

Animal exposure

Exposure to domestic or wild animals can also be a factor. The easily acquired Blastomycosis in dogs makes them sentinels that warn people of the contamination by the fungus in an area. Based on the zoonotic potential, the risk for infection will thus surge for people who often approach infected animals or have direct contact with them and their discharges, or for those who frequently visit places where such animals are commonly found.3

Travel history

Travel to areas endemic for Blastomycosis increases the chance of an infection. Even if a person lives in a low-risk area, travelling to high-risk areas and activities ending in soil disturbance expose one to the pathogen. There is a need for travellers to be aware of the risk and take precautions when visiting these endemic areas.4

Prevention Strategies

Prevention of Blastomycosis follows several strategies that involve reducing exposure to these fungal spores. Individual protection measures, like face masks and protective clothing, will prevent inhalation during soil-soil disturbance activities. Good hygiene-washing hands and changing clothes after being outdoors-will also reduce the risk. Of equal importance are the measures of environmental control that reduce exposure in risky areas and ensure that soil and organic material are handled by safe means.

Summary

Therefore, as with most other infections, awareness of the identifiable risk factors will lessen the likelihood of falling victim to a potentially more serious infection, such as Blastomycosis. One is able to realize that predisposing factors, including the geographic area, environmental variables, occupation and avocation, host factors, demography, animal exposure, and the history of the area of travel, do have an influence on the individual in relation to personal preventive measures. For it is in living the concept of awareness combined with preventive measures, especially on the part of those living in high-risk areas or with health conditions that are unusually compromised, that the key effort of mitigating the risks associated with the infectious disease of Blastomycosis. This paper has pointed out most of the important risk factors, together with necessary advice. Having followed these guidelines, individuals can significantly lower their chances of contracting blastomycosis and therefore maintain better overall health.

References

  1. CDC. Blastomycosis. 2024 [cited 2024 Jul 25]. Risk factors for blastomycosis. Available from: https://www.cdc.gov/blastomycosis/risk-factors/index.html.
  2. Rayens E, Rayens MK, Norris KA. Demographic and socioeconomic factors associated with fungal infection risk, united states, 2019. Emerg Infect Dis [Internet]. 2022 Oct [cited 2024 Jul 25];28(10):1955–69. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514344/.
  3. Schwartz IS. Blastomycosis in mammals. Emerging and Epizootic Fungal Infections in Animals [Internet]. 2017 Dec 14 [cited 2024 Jul 25];159–76. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122209/.
  4. Alvarez AM, Vega M, Rathore M. Traveling does more than widen one’s horizon: travel history as key to diagnosing blastomycosis. Cureus [Internet]. [cited 2024 Jul 25];15(5):e38551. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243411/.
  5. Castillo CG, Kauffman CA, Miceli MH. Blastomycosis. Infect Dis Clin North Am. 2016 Mar;30(1):247–64.

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Bibek Rana Chhetri

Masters in Science- Biomedical Sciences, University of Chester, UK

Bibek, from Nepal, is a burgeoning scholar in the field of Biomedical Sciences, currently advancing his studies with a Master’s degree at the University of Chester, UK. His academic journey began with a Bachelor’s degree in Microbiology from St. Xavier’s College, Nepal, where he first cultivated his deep-seated enthusiasm for microbiology. With a robust background as a public health content writer back home, Bibek has successfully bridged the gap between scientific inquiry and public engagement. He has contributed to diverse research projects, including original research, narrative reviews, systematic reviews, and meta-analyses, demonstrating a keen aptitude for critical scientific evaluation and data synthesis. Bibek’s commitment to the microbiological sciences continues to grow as he contributes to the scientific community and healthcare advancements.

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