Introduction
A complicated and multidimensional element of human health, fertility, is regulated by a wide range of circumstances. Stress has become one of the main factors that negatively impact reproductive health. Stress can take one different forms, such as emotional, psychological, or physical stress. It is a normal reaction to perceived threats or obstacles. Stress triggers the body’s “fight or flight” reaction, which releases adrenaline and cortisol. Although this reaction is essential for handling threats that arise right away, prolonged stress can cause a number of health problems, including effects on reproductive health.1
Understanding stress and its effects on fertility
It is very important to understand the types of stress before discussing their effects on fertility. Stress is categorised into acute or chronic.
Acute stress is a transient response to an impending danger or difficulty, like a job interview or a small mishap. This kind of stress usually goes away after the issue is fixed and might be advantageous in that it improves performance and focus.
On the other hand, chronic stress is more lasting and results from ongoing circumstances, such as a demanding job or a persistent disease. In contrast to acute stress, chronic stress lasts for an extended length of time and, if left unchecked, can have a negative impact on one's health, including anxiety, depression, and cardiovascular disorders.2
Biology of the stress response
The hypothalamus and pituitary gland of the brain and adrenal glands combine to form the hypothalamic-pituitary adrenal (HPA) axis. This is a key stress response mechanism.
Adrenocorticotropic hormone (ACTH) is secreted by the pituitary gland in response to stimulation by corticotropin-releasing hormone (CRH), which is released by the hypothalamus in response to stress. The main stress hormone, cortisol, is then released by the adrenal glands in response to ACTH.3
Cortisol then exerts its actions on various organs to elevate blood sugar, improve brain function, and inhibit non-essential processes like digestion and reproduction. This series of actions primes the body to react to stress and helps it deal with it.
Even though cortisol is necessary for handling acute stress, a persistently high level of it might be harmful. Extended elevated cortisol levels have been shown to impair immunological response, digestion, and reproductive systems, among other body processes. Elevated cortisol can affect ovulation and the menstrual cycle in women, but it can also lower testosterone levels and affect the development of sperm in men.4 Chronic elevated cortisol is also linked to higher levels of anxiety, depression, and other health problems.
Stress influences fertility in a number of ways, including:
Hormonal disruption
Prolonged high cortisol levels brought on by chronic stress can disrupt the hypothalamic pituitary-adrenal axis (HPA axis). The release of reproductive hormones like oestrogen and testosterone, which are essential for healthy reproduction, may be impacted by this disturbance.
Ovulation and menstrual cycles
Stress has the potential to affect a woman’s menstrual cycle consistency. It can interrupt or delay ovulation or lead to the complete loss of ovulation (anovulation). This makes conception harder and more challenging. In addition, stress can make diseases like polycystic ovarian syndrome (PCOS) which is linked to irregular menstrual cycles and problems with conception, worse.5
Sperm quality
Stress affects sperm motility, count, and morphology; which can lower sperm quality in males. Reduced testosterone levels have been linked to elevated stress levels, and this can have an adverse effect on the process of sperm production, referred to as spermatogenesis.6
Sexual dysfunction
Stress can lower sexual desire and performance, which can impact the chance of conception, and can lead to sexual dysfunction in both men and women.
Immune system impact
Prolonged stress can weaken the immune system, which reduces its capacity to fight infections and may have an impact on reproductive health.
Strategies for coping with stress to enhance fertility
Considering how much stress affects fertility, it is critical to develop healthy coping mechanisms to reduce stress and enhance reproductive health. It is worth noting that the coping process takes time and is not uniform, rather it is dynamic and changes depending on each case.7
Several approach may be implemented:
Meditation and mindfulness
The main goals of mindfulness and meditation practices are to encourage calmness and awareness of the present moment. These techniques can ease tension by promoting physical and mental clarity. Studies have indicated that practising mindfulness-based stress reduction, or MBSR, can reduce cortisol levels and enhance emotional health in general. People can manage stress better and lower its effects on fertility by implementing such practices into their daily lives.8 Techniques like guided meditations and deep breathing are very beneficial for 10-15 minutes daily.
Cognitive behavioural therapy (CBT)
The goal of cognitive behavioural therapy, which is a short-term systematic psychotherapy, is to recognise and change maladaptive thought patterns and behaviours. An example would be changing negative thought patterns which yield unhelpful behavioural outcomes. To illustrate, low self-esteem and feelings of worthlessness may cause the person to socially withdraw from friends and family. CBT can help to break this perpetuating cycle.
Because CBT assists people in acquiring more constructive coping strategies and problem solving techniques, it can be very useful in the management of stress.
Research indicates that cognitive behavioural therapy helps mitigate stress and enhance the standard of living for those undergoing infertility treatments.
Physical exercise
Frequent exercise is proven to lower stress and enhance general health. Exercise encourages the release of endorphins, which naturally elevate mood. Exercise can also enhance blood flow and regulate hormones, both of which may have a good impact on reproductive health.
On most days, it is recommended to spend at least 30 minutes doing a moderate form of exercise, such as yoga, swimming, or walking. Exercise regimens should be customised based on each person’s interests and fitness level.
Lifestyle changes
The adverse effects resulting from stress can be lessened by leading a healthy lifestyle. This entails eating a balanced diet, getting enough sleep, and abstaining from drugs and alcohol. In addition to promoting general health and enhancing fertility, a diet high in fruits, vegetables, and lean meats is very nutritious due to containing all the vitamins and minerals we require.
Social support
Emotional relaxation and stress reduction can be obtained from having a solid support system. During trying times, support from friends, family, and partners may be consoling and uplifting. Furthermore, support groups created especially for people with infertility problems can offer insightful information and wealth of personal experience.
Relaxation techniques
Other relaxation methods, in addition to meditation, can be useful in stress management. Deep breathing techniques, progressive muscle relaxation, and aromatherapy are a few methods that can ease physical stress and encourage relaxation.
Professional guidance
It is imperative that those who are under severe stress or are having problems conceiving consult a professional. Counsellors and fertility specialists can offer individualised guidance and treatment alternatives. Combining medical care with stress reduction techniques can improve the overall conception strategy.
Future research
Even though a lot of research has been done on the stress mechanisms of the body and the effect of short-term as well as long-term stress on bodily functions, more studies need to focus on the proper methods of coping with stress. Most prior research has solely focused on physical or mental health while dealing with stress, excluding the other.
However, studying both simultaneously allows for the creation and implementation of precise methods to decrease the effects of stress and help patients cope with challenges, namely infertility.
Since prolonged stress is related to an increase in physical and emotional health vulnerability, it is imperative that patients seek professional help. It is equally crucial to equip medical professionals with the proper techniques to help patients cope with stress-induced infertility.
Summary
Stress is an important component that, via a variety of physiological and psychological pathways, can have a negative impact on fertility. Comprehending the impact of stress on reproductive health is essential for formulating efficacious coping mechanisms.
People can improve their ability to handle stress and increase their chances of being fertile by combining mindfulness and meditation, cognitive behavioural therapy, physical exercise, healthy lifestyle choices, social support, relaxation techniques, and expert assistance.
Understanding that managing stress is not a panacea but rather a vital part of an all-encompassing strategy for reproductive health is crucial. Proactively managing stress can enhance general wellbeing and possibly improve the success of reproduction.
References
- Choi, Y. and Moon, S.-H. (2023) Types and characteristics of stress coping in women undergoing infertility treatment in Korea, International journal of environmental research and public health. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915192/
- Ilacqua, A. et al. (2018) Lifestyle and fertility: The influence of stress and quality of life on male fertility, Reproductive biology and endocrinology : RB&E. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260894/
- Joseph, D.N. and Whirledge, S. (2017) Stress and the HPA axis: Balancing homeostasis and fertility, International journal of molecular sciences. Available at: https://pubmed.ncbi.nlm.nih.gov/29064426/
- Malcolm, X. (2021) The 3 different types of stress and how each can affect our health, Health Beat. Available at: https://www.flushinghospital.org/newsletter/the-3-different-types-of-stress-and-how-each-can-affect-our-health/
- Palomba, S. et al. (2018) Lifestyle and fertility: The influence of stress and quality of life on female fertility, Reproductive biology and endocrinology : RB&E. Available at: https://pubmed.ncbi.nlm.nih.gov/30501641/
- Rooney, K.L. and Domar, A.D. (2018) The relationship between stress and infertility, Dialogues in clinical neuroscience. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016043/
- Samuels, M. (2018) Stress reduces fertility in women., SPH Stress Reduces Fertility in Women Comments. Available at: https://www.bu.edu/sph/news/articles/2018/stress-reduces-fertility-in-women/
- Stressors: Coping skills and strategies (2020) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/articles/6392-stress-coping-with-lifes-stressors
- Zhu, H. et al. (2022) Global research trends on infertility and psychology from the past two decades: A Bibliometric and visualized study, Frontiers in endocrinology. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317298/