Understanding HPV-Related Mouth Sores: Causes And Prevention
Published on: May 30, 2025
HPV-Associated Oral Lesions Pathogenesis and Prevention
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Akanksha Suryvanshi

Bachelor of Dental Surgery- BDS, Ahmedabad Dental, College and Hospital, India

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Wiktoria AbramowiczE

Master of Science in Physician Associate Studies (Year 2), completing in 2025

Introduction

Human papillomavirus functions, or HPV, is a very common virus that can cause different types of sores or growths in the mouth and throat. Some types of HPV can lead to health problems like cervical cancer and mouth and throat cancers. Doctors are learning more about how HPV causes these mouth sores and why some people are at higher risk. Understanding how the virus works, what causes it, how to spot it early, and ways to prevent it helps people stay healthy and get treatment sooner.

How HPV causes mouth sores

HPV enters the mouth through tiny cuts or openings you might not even notice. Once inside, the virus changes the way cells grow, making them multiply too much or not die when they should. This can cause different types of mouth sores.

Some HPV types, like 6 and 11, cause harmless warts or bumps, while types 16 and 18 are more dangerous because they can sometimes lead to mouth or throat cancers. If HPV stays in the mouth for a long time, it can slowly change the tissue from normal to unhealthy, and in rare cases, to cancer.

Causes and risk factors

The causes of HPV-associated oral lesions develop because of following elements:

  • HPV spreads mainly through close contact inside the mouth or with the genital area, such as during oral sex or kissing
  • People with weaker immune systems, like with HIV or who take certain medicines, are more likely to get these sores
  • Smoking and drinking alcohol for a long time can also make it easier for HPV to cause problems 
  • Having many sexual partners raises the chance of getting HPV, and not taking good care of your mouth can make it easier for the virus to stay

Everyone’s body is different, so some people might be more likely to get mouth sores from HPV than others.

Signs and symptoms

HPV can cause different kinds of mouth problems. Sometimes, small bumps that look like tiny cauliflower or warts appear on the tongue, lips, roof of the mouth, or inside the cheeks. Other times, soft pink clusters may form in the mouth. Children might develop multiple flat bumps on their mouths, known as Heck’s Disease. Some people get white or red patches inside their mouths that don’t go away, which can sometimes become cancerous. If you have a sore throat that lasts a long time, trouble swallowing, a hoarse voice, ear pain, or mouth sores that don’t heal, you should see a doctor.

Diagnosis

To find out if HPV is causing mouth sores, a doctor will carefully look inside your mouth and feel any unusual spots. Sometimes, a small sample of tissue may be taken in a quick and simple procedure called a biopsy. This helps the doctor understand if the sore is harmless or something more serious. There are also special lab tests that can find HPV in the tissue or even in saliva, which is easy and painless. These tests help doctors decide the best treatment for you.

Management and treatment

Treatment depends on what kind of mouth sore you have and how serious it is.

For harmless warts or bumps, doctors can remove them with a small surgery or lasers. If there are sores that might turn into cancer, your doctor will watch them closely or remove them to prevent problems. If cancer does develop, treatments can include surgery, radiation, and medicines that help your body fight the cancer. New medicines can help your immune system fight the cancer better, improving chances of recovery.

Prevention strategies

Preventing HPV-related mouth problems is very important. 

Vaccines like Gardasil-9 protect against the types of HPV that can cause cancer. 

Practising safer sex, like limiting the number of partners and using protection during oral sex, can reduce your risk.

Avoiding smoking and drinking too much alcohol also helps because these habits make it easier for HPV to cause problems. Regular visits to your dentist can catch any mouth changes early, making treatment easier. Learning about HPV and how it spreads helps everyone stay healthier. 

FAQ’s

What is HPV, and can it cause cancer?

HPV is a common virus that can cause warts and sometimes leads to cancer in the mouth, throat, or cervix. Most people with HPV don’t get cancer, but certain types can increase the risk if the infection lasts a long time.

How does HPV spread? 

It spreads through close contact, including oral sex and kissing.

What are the signs to watch for? 

Warts, white or red patches, or sores that don’t heal.

How do doctors check for HPV??

They look inside your mouth and may take a small tissue sample or use simple saliva tests

CanHPV sores become ancer?

Sometimes, especially with certain types of HPV, long-term infection can lead to cancer.

Summary

HPV can cause different types of sores and growths in the mouth and throat. Most are harmless, but some types of HPV can lead to cancer over time. The virus spreads mainly through close contact like oral sex. Doctors can find these problems by checking symptoms and doing simple tests. Treatments range from removing warts to cancer therapies. The best way to stay healthy is by getting vaccinated, avoiding smoking and heavy drinking, practising safe sex, and visiting your dentist regularly. Knowing about HPV helps you spot problems early and get the right care.

References

  • Syrjänen S. Oral manifestations of human papillomavirus infections. European Journal of Oral Sciences. 2018 Sep 3;126(S1):49–66.
  • Betz SJ. HPV-Related Papillary Lesions of the Oral Mucosa: A Review. Head and Neck Pathology. 2019 Jan 29;13(1):80–90.
  • Federica Di Spirito. Human Papillomavirus: Oral Lesions and Vaccination. Cancers. 2023 May 11;15(10):2711–1.
  • HPV in the mouth: Symptoms, causes, and treatment [Internet]. www.medicalnewstoday.com. Available from: https://www.medicalnewstoday.com/articles/322362
  • Bouda M, Gorgoulis VG, Kastrinakis NG, Giannoudis A, Tsoli E, Danassi-Afentaki D, et al. “High Risk” HPV Types Are Frequently Detected in Potentially Malignant and Malignant Oral Lesions, But Not in Normal Oral Mucosa. Modern Pathology. 2000 Jun;13(6):644–53.
  • Graham Sheila V. The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review. Clinical Science [Internet]. 2017 Aug 10;131(17):2201–21. Available from: https://portlandpress.com/clinsci/article/131/17/2201/71573/The-human-papillomavirus-replication-cycle-and-its
  • The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis. Oral Oncology [Internet]. 2018 Jul 1;82:91–9. Available from: https://www.sciencedirect.com/science/article/pii/S1368837518301283

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Akanksha Suryvanshi

Bachelor of Dental Surgery- BDS, Ahmedabad Dental, College and Hospital, India

Dr. Akanksha is a general dentist with over 1 year of experience children and adults to promote healthy dental habits. She is going to start her Master of Science in Clinical Epidemiology from Kent State University, Ohio, USA. She also has research experience. And currently also work as medical writer for Klarity to write medical articles for spreading awareness and also for providing health benefit knowledge to the community.

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