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Ayesha Ingham Folami

Master of Science (MSc) – Biomedical Engineering, <a href="https://www.southampton.ac.uk/" rel="nofollow">University of Southampton, England</a>

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Harry White

Master of Science - MS, Biology/Biological Sciences, General, University of Bristol, UK

Introduction

Scars are formed as part of the body’s healing process, they are fibrous tissue that replaces normal skin after damage. The appearance and characteristics of scars are dependent on the type and circumstance of the injury, and the healing process.

Scars form as a protective mechanism to close and heal wounds,1 they can occur anywhere on the body, and their appearance can be influenced by various factors, such as wound size and depth, location, and genetics.2

It is important to understand scars for many reasons. Scars can severely impact an individual’s physical and emotional health – having a huge impact on their quality of life, self-esteem, and body image. This makes addressing the physical and psychological aspects of scars very important.3 Scars also aid healthcare professionals in their decision-making regarding wound care, surgeries and scar management.4

This article will provide a good overview of scars – such as scar type, formation, characteristics, prevention, and management.

Types of scars

Scars have various forms with their own characteristics and causes. Knowing and understanding the different types is important in finding management strategies.

Hypertrophic scars

Hypertrophic scars are raised and typically red or pink. These scars occur at an injury site and usually stay within the original wound boundaries. Hypertrophic scars happen due to an overproduction of collagen during the wound-healing process. These scars are more common in people who are genetically predisposed to excessive scarring and may occur after burns, surgeries, or traumatic injuries.5

Keloid scars

Keloid scars are similar to hypertrophic scars, however, they extend beyond the boundaries of the initial wound. This scar type is characterised by excessive collagen production – they will grow larger and thicker over time. Keloids are usually darker in colour and more commonly occur in people with darker skin tones. According to a study in the Journal of Investigative Dermatology, genetics have a significant role in the formation of keloid scars, and they can develop spontaneously, or from minor injuries.6

Atrophic scars

Atrophic scars are flat or depressed – resulting from conditions like acne, chickenpox, or surgical procedures. These scars are due to insufficient collagen production during wound healing – creating a sunken appearance.7

Contracture scars

Contracture scars are associated with burns – causing skin tightness and movement restriction in the affected area. The significant functional implications of contracture scar can require specific medical treatment.8

Stretch marks

Stretch marks occur when the skin stretches rapidly. They can occur from pregnancy, growth, or rapid weight gain. These scars appear as streaks or lines, lighter in colour than the surrounding skin. Stretch marks happen due to the skin’s dermal layer excessively stretching - leading to scar formation.9

Understanding scar types is important in gaining the appropriate treatment and management, as each type has unique characteristics and may respond differently to care.

Formation of scars

Scar formation is tied to wound healing, which happens in several stages.

Wound healing process

Inflammatory phase

The inflammatory phase is the body’s first response to a tissue injury. In this phase, blood vessels will tighten to reduce bleeding. Platelets then begin the clotting process. Inflammatory cells (known as neutrophils and macrophages) remove foreign substances and damaged tissue. This phase happens for a couple of days, prior to the subsequent phases of wound healing. The inflammatory phase is important in preparing the wound for tissue repair and regeneration.10

Proliferative phase

During the proliferative phase, new tissue starts replacing damaged tissue. Fibroblast cells play a big part in collagen production (the structural protein that strengthens the wound). Then blood vessels regenerate – causing the wound to slowly contract. This phase can last for weeks, and collagen formation is a crucial factor In the texture and appearance of the scar.11

Remodelling phase

The remodelling phase can occur over several months. This stage involves the newly formed tissue maturing and reorganising itself. Collagen fibres align due to tension and stress on the scar. The final appearance of the scar is influenced by this phase and the collagen production and degradation balance. Understanding the mechanisms of collagen remodelling is important for scar management.12

Factors influencing scar formation

The wound healing process and scar formation can vary, due to several factors, such as:

Genetics

Genetics play a large role in one’s predisposition to certain scars, such as hypertrophic or keloid scars.

Wound size and depth

Wound depth and size are important in determining scar formation – larger or deeper wounds will result in more prominent scars.

Location on the body

Wound location will also influence scar appearance. Areas with thinner skin, (e.g., the face), are more likely to have noticeable scars.

Skin type and colour

Skin type and colour play a role in scar development. People with darker skin tones are more prone to keloid scars, whereas fair skin tones may develop more obvious red or pink scars.

Understanding these factors and how they impact scar formation is important for medical professionals and those attempting to manage or prevent scars effectively.

Characteristics of scars

Scars can vary in appearance, with  distinct characteristics that affect said  appearance and the impact they have on one’s life.

Colour

A scar’s colour is a prominent characteristic that can gradually change. Scars typically start as red or pink and slowly get lighter, only reaching their final colour over months or years.  Skin type and location impact scar colour. The colour of a scar is also associated with the gradual maturation and remodelling of collagen in scar tissue.

Texture

Scar texture is an important feature. The texture of scars can be smooth, raised, or depressed – this is dependent on the balance between collagen production and degradation during the healing process. Raised scars, like hypertrophic and keloid scars, are categorised by excess production of collagen, whereas atrophic scars are due to a deficiency in collagen production.

Size

A wound's size and depth will impact scar size. Larger wounds typically lead to more extensive scarring, such as with surgical incisions.

Sensation

The sensation caused by a scar can vary for everyone. Some scars can be sensitive, leading to itching, pain, or discomfort. Scar sensation can be influenced by location and pain threshold.

Understanding scar characteristics is important in evaluating severity and therefore finding an appropriate management strategy. Scar appearance and sensation can negatively impact an individual's self-esteem and quality of life, hence it is important to address these aspects while considering scar treatment options.

Medical and cosmetic concerns

Scarring can greatly impact physical and mental well-being - understanding these concerns is essential for effective scar management.

Scar contracture and mobility

Scar contracture is the tightening of scar tissue – this may restrict the movement of neighbouring structures – which can create issues if formed over joints or highly mobile areas.

Scars over joints

Scarring over joints (e.g., knees or elbows) can reduce one’s range of motion and create discomfort. Contracture scars might need specialist treatment, such as physical therapy or surgery, to restore proper joint functionality.

Emotional and psychological impact

Scarring can have a large emotional and psychological impact – causing poor self-esteem, body image issues, anxiety, or depression.

Cosmetic concerns

Cosmetic concerns related to scars are common – raised, discoloured, or irregularly shaped scars can cause self-consciousness or a desire to conceal the affected area. This can impact a person's confidence and quality of life.

Surgical techniques

Scar revision surgery is optional for those attempting to improve the appearance of scars. Scar excision, dermabrasion, or laser resurfacing can effectively reduce the size, texture, and colour of scars.

Non-surgical treatments

Non-surgical scar revision treatments are less invasive, whilst still improving scar appearance. These techniques include silicone sheets and gels, steroid injections, and laser therapy.

Understanding the medical and cosmetic concerns of scarring is important for both healthcare professionals and individuals with scars. Addressing these concerns can improve quality of life and well-being.

Scar prevention and management

Effective scar prevention and management can make a large difference in a scar's impact and appearance. Understanding and applying these techniques is crucial to individuals wanting to reduce the long-term effects of scars.

Proper wound care

Proper wound care is crucial in preventing infection and promoting healing - this includes keeping the wound clean, moist, and protected.

Minimising tension on wounds

Placing tension on wounds can cause increased scarring. Sutures or adhesive strips can bring wound edges together to reduce tension.

Sun protection

Sun exposure can make scars more noticeable by increasing pigmentation – by applying sunscreen to scars and protecting them from UV rays,  hyperpigmentation can be prevented.

Scar creams and ointments

Over-the-counter scar creams and ointments can help to reduce the appearance of scars. These products often contain silicone and vitamin E.

Silicone sheets and gels

Silicone sheets and gels are effective in scar management – helping to maintain hydration, flatten scars, and improve their overall appearance.

Steroid injections

Steroid injections are for treating hypertrophic and keloid scars – to reduce inflammation and excess collagen production.

Laser therapy

Laser therapy is a non-invasive scar management technique. Different lasers can target different aspects of scar tissue, including colour and texture.

Massage and physical therapy

Massage and physical therapy techniques aid in breaking down scar tissue and provide greater mobility. Specific exercises and massages can be useful in managing scar contractures and maintaining joint function.

A combination of these scar prevention and management techniques can lead to better scar outcomes and therefore improve overall well-being.

Conclusion

Scars are a result of the body's natural healing process. There are various types, with different characteristics, and causes. Scars influence physical, emotional, and psychological well-being – therefore scar prevention and management are essential.

The body has an exceptional ability to heal and adapt to injuries. Scars show the body's remarkable capacity for self-repair, commonly resulting in improved function and strength at the previous wound site.

It is important to foster a positive attitude towards scars, both individually and within society. By gaining a deeper understanding of scars, alongside their cultural and societal significance, and impact on self-esteem, we can promote self-acceptance.

Scars are natural, and by recognising their significance and offering support, we can enhance the way we perceive and interact with these marks of healing and survival.

References

  1. American Academy of Dermatology. "Scars: Overview". [Internet]. Accessed September 10, 2021. Available from: https://www.aad.org/public/diseases/a-z/scars-overview
  2. Broughton G, Janis J, and Attinger CE. "The Basic Science of Wound Healing." Plastic and Reconstructive Surgery. (2006). 117, no. 7S : 12S-34S.
  3. Lawrence JW, Mason RW, and Schomer TE. "The Effect of Scar Pain on Daily Activities." British Journal of Dermatology. (2001). 145, no. 2: 259-263.
  4. Mustoe TA, Cooter G, Alghoul W, Karp JN, Schaverien AA, and Patel JA. "International Clinical Recommendations on Scar Management." Journal of Clinical Medicine. (2014). 3, no. 4: 1195-1217.
  5. Gauglitz, GG, Korting, HC, Pavicic T, Ruzicka T, & Jeschke MG.  Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies. Journal of Plastic, Reconstructive & Aesthetic Surgery (2011). 64(2), 131-141.
  6. Shih B and Bayat A. Genetics of Keloid Scarring. Journal of Investigative Dermatology. (2012). 132(6), 1506-1513.
  7. Savant SS.. Postacne Scarring: A Review. Journal of Cutaneous and Aesthetic Surgery. (2012). 5(2), 88-95.
  8. American Burn Association.. Standards and Practice Guidelines for Burn Care: Contracture Scars. [Internet]. (2021). Available from: https://ameriburn.org/quality-care/standards-and-guidelines/standards-and-practice-guidelines-for-burn-care/contracture-scars/. 
  9. Elsaie ML, Baumann LS, and Elsaaiee LT.  Striae Distensae (Stretch Marks) and Different Modalities of Therapy: An Update. The British Journal of Dermatology. (2009). 161(4), 672-682.
  10. Schultz GS, & Wysocki A. Wound Hygiene: What's in a Word? Journal of Wound Care. (2009). 18(8), 333-338.
  11. DiegelmannRF, & Evans MC. Wound Healing: An Overview of Acute, Fibrotic and Delayed Healing. Frontiers in Bioscience. (2004). 9, 283-289.
  12. Shih B, & Bayat A. Genetics of Keloid Scarring. Journal of Investigative Dermatology. (2012). 132(6), 1506-1513.
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Ayesha Ingham Folami

Master of Science (MSc) – Biomedical Engineering, University of Southampton, England

Ayesha is a Biomedical Engineer with a Master of Science (MSc), with a passion for improving the lives of others with cutting-edge medical solutions. Having earned her MSc from The University of Southampton, Ayesha honed her skills in medical device design, bioinformatics and biomechanics. Ayesha brings a distinctive blend of scientific acumen and passion for writing, making her work enlightening, engaging and accessible.

With an unwavering commitment to bridging the gap between engineering and healthcare, Ayesha continues to utilise her knowledge and dedication to improving healthcare.

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