Did you know that managing gum inflammation resulting in bleeding gums during pregnancy reduces the likelihood of low birth weight babies and preterm delivery?
This information comes from recent research conducted at the University of Sydney. According to Professor Joerg Eberhard, Chair of Lifespan Oral Health at the University of Sydney School of Dentistry and the Charles Perkins Centre, treating gum inflammation during pregnancy lowers the likelihood of a baby being born preterm by 50 percent. Gum inflammation, or gingivitis, is characterised by redness, swelling, and pain. It is typical during pregnancy and disappears following childbirth.
Are you interested in finding out how the health of your unborn child and yourself pertains to pregnant gingivitis? Explore the reasons, unexpected effects, and crucial preventative advice in more detail. To be sure you have the information necessary to start a safe and joyful pregnancy experience, continue reading.
Introduction
Studies on periodontal health in pregnant assigned females at birth (AFAB) have expanded since the 1960s when the topic first emerged as a field of study. Gingival inflammation associated with pregnancy has been initiated by dental plaque and exacerbated by endogenous steroid hormones. Since the early 1960s, there has been a reported rise in the prevalence and severity of gingival inflammation during pregnancy without any correlation with plaque.
Clinically, a pregnant AFAB would have a significant exacerbation of any previous gingivitis or periodontitis. Probing further into the periodontal tissues, bleeding when urged or stimulated mechanically, and gingival crevicular fluid (GCF) flow that stops after childbirth are the hallmarks of periodontal alterations.
Previous research suggests that gingival inflammation varies in prevalence in pregnancy, from 30% to 100%. Meanwhile, a cross-sectional study revealed that 89% of pregnant AFAB in Ghana, 86.2% in Thailand, and 47% in Brazil had gingivitis during their pregnancy. The variance in periodontal disease criteria across research and the various groups under investigation might cause this variation.
Sustaining dental and oral health over an extended period requires appropriate and efficient care. In AFAB, getting dental care is crucial during menopause, breastfeeding, and pregnancy. Pregnant AFAB may have early delivery, low birth weight babies, pre-eclampsia, gingival tissue ulcerations, pregnancy granuloma, gingivitis, pregnancy tumours (Epulis gravidarum), loose teeth, dry mouth, and dental erosions as a result of poor oral hygiene.1,2
Cause of pregnancy gingivitis
Pregnancy-related hormonal changes and an increased vulnerability to bacterial growth are the primary causes of gingivitis.
Hormonal surge
The specific clinical feature is linked to the notable increase in progesterone and oestrogen levels in the bloodstream during the 1970s, impacting the periodontium during pregnancy. Due to continual production by the placenta later in pregnancy and the corpus luteum at the beginning, both are high during pregnancy.
Oestrogen, either directly or indirectly, exerts a substantial effect on gingival physiologic processes, including cell proliferation and differentiation. In the gingival tissues of expectant AFAB, progesterone acts as an immunosuppressant, inhibiting the quick acute-type inflammatory response to plaque while permitting an increased chronic-type tissue reaction, which leads to a clinically exaggerated appearance of inflammation.
Changes in the subgingival microbiota
Subgingival microbes exist in the periodontium. The cause for the increased gingival inflammation during pregnancy may be due to modifications in the subgingival flora. The pathogens associated with pregnancy gingivitis include Bacteroides intermedius, Porphyromonas gingivalis, Tannerella forsythia, Campylobacter rectus and Fusobacterium nucleatum. Despite different approaches, research studies about Bacteroides species yield inconclusive findings. Research is required to understand how the subgingival microbial profile of pregnant AFAB changes.
Modifications to the host immunoinflammatory response
Polymorphonuclear leukocytes (PMNs) are the primary effector cells in the gingival inflammation process and seem to be crucial components in the numerous immunological systems involved. Stimulation by bacterial pathogens, host cells release proinflammatory cytokines as a part of the immune response. By attracting PMNs to the infection site, these cytokines release a range of physiologically active substances, including chemokines, proteolytic enzymes and reactive oxygen species (ROS), indirectly influencing gingival inflammation.1,3
Symptoms
Taking timely action and maintaining optimum oral health while pregnant, it is imperative to recognise the symptoms of pregnancy gingivitis. An illustration below depicts the condition's symptoms.
Created by: Deepika Rana (Created with Biorender.com)
The preexisting gingivitis worsens during pregnancy; this becomes more apparent in the second month and peaks in the eighth. The last month sees a noticeable decline in gingivitis, and the gingival tissues revert to their prepartum state after giving birth. It is seen more commonly in the front teeth.4,5,6
Impact on pregnancy
By controlling the release of inflammatory mediators, periodontal pathogens and their metabolites are widely acknowledged to impact progressive and inflammatory lesions of tissues supporting teeth. Additionally, these agents can spread to the placenta and contribute to several unfavourable pregnancy outcomes. The table lists the effects of each on pregnancy.
| Influencing factor | Adverse pregnancy outcome |
| Periodontal pathogen infection: Porphyromonas gingivalis(Gram-negative anaerobic, rod-shaped bacteria) Fusobacterium nucleatum (Gram-negative anaerobic bacteria) | Intrauterine infections lead to 25-40% premature births. -Disrupts maternal endothelium and triggers systemic inflammatory responses -Pre-eclampsia -Impacts foetal blood, causing malnutrition and deathUterine inflammation Placental inflammation |
| Increased levels of inflammatory mediators by periodontal disease | Systemic inflammatory response during pregnancy results in low birth weight, preeclampsia and preterm babies |
| Host immune responseElevated IgM and IgG antibodies | Preterm infants |
| Antiphospholipid syndrome (APS) with elevated anticardiolipin antibodies (aCL) | Increased levels of aCL cause thrombosis, miscarriage, and early birth7 |
Management and prevention
A combination of these factors is involved in preventing and managing pregnancy gingivitis.
Oral hygiene practices
For optimal dental health, practise good daily hygiene. Brush your teeth thoroughly twice daily with fluoride toothpaste to remove plaque and help prevent caries, tooth decay, and gum disease. Make sure you use floss or a similar interdental cleaner to clean your teeth once a day. Ask your hygienist or dentist to demonstrate proper brushing and flossing techniques. Keep visiting your dentist for professional teeth cleanings and oral exams during pregnancy. Inform your dentist about any changes you have seen in your oral health.
Dietary patterns and supplementation
Pregnancy-related nutrition is crucial for the birthing parent's (mother's) overall health and the baby's dental health. A baby's teeth erupt between weeks five and six of pregnancy. The birthing parent has to take 1200–1500 mg of calcium every day to ensure the health of both her own and her child's bones. A healthy diet must include foods high in calcium, phosphorus, and the vitamins A, D (which aid in the development of enamel), and C, as well as fruits, vegetables, cereal, milk, dairy products, meat, fish, and eggs. Try to limit your sugar intake, especially between meals. Avoid dried fruits and toffees.
Lifestyle modifications
Abstain from alcohol and tobacco as they harm the growth of the foetus. Smoking harms dental health, particularly on the gums. Smokers have higher rates of periodontal disease and inflammation with an increased risk of stillbirth or abortion. The baby's birth weight is also lower than average when born alive. Overuse of alcohol consumption is teratogenic in babies and can cause foetal alcohol syndrome (FAS). Drinking alcohol can cause dental anomalies such as small teeth, enamel structural degeneration, and delayed tooth rupture.2,9
Professional treatment options
Pregnancy gingivitis can be treated professionally with procedures done by dentists to treat and control the disease. The goals of therapies are to reduce gum disease overall, manage infection, and lessen inflammation.
X-ray scans, plaque removal, teeth scaling, root planing (removal of plaque and tartar from below the gum line (scaling), smoothing of the tooth roots (root planing), polishing and local anaesthetics are all possible procedures during routine dental visits. Treatment (plaque control, scaling, and daily rinsing with 0.12% chlorhexidine) and maintenance (oral hygiene education and manual supragingival (above the gum line) plaque removal every two to three weeks until delivery) significantly reduced the risk of preterm birth, according to a randomised controlled trial of 870 AFAB with pregnancy-associated gingivitis. The Journal of the Canadian Dental Association states that using local anaesthetics during pregnancy is safe but also emphasises the need for aspiration to reduce the risk of intravascular injection.10
FAQs
Are dental procedures safe during pregnancy?
The dental procedures are safe during pregnancy. Various management guidelines for the several trimesters appear in the table below.
| Trimester and medications | Dental procedure recommended |
| First trimester (1-12 weeks) | -Educating patients about the oral changes across pregnancy -Oral hygiene instructions with plaque control -Restricting dental care to emergency care and periodontal prophylaxis only -Routine radiographs ought to be applied selectively and only when necessary |
| Second trimester (13-24 weeks) | -Plaque control, guidance, and dental hygiene -Scaling, polishing, and root planing if necessary -Elective dental care is safe -Abstain from routine radiographs |
| Third trimester (25-40 weeks) | -Do not get elective dental work done in the second or third trimester of pregnancy |
| Medications safe during pregnancy | -Analgesics -Antibiotics (penicillin, tetracycline and amoxicillin) -Sedatives/hypnotics (nitrous oxide, barbiturate benzodiazepines)8 |
What are the risk factors for pregnancy gingivitis?
Higher levels of education and a higher monthly household income are associated with lower rates of gingivitis. Lack of oral health facilities, supplies, and staff shortage restricts preventative services in many low-income countries and rural locations. Inconsistent brushing and flossing practices lead to plaque accumulation, smoking, alcohol use, prolonged stress, and advanced age all raise the risk of pregnant gingivitis. Insufficient dietary intake influences dental inflammation and gingivitis.5,11
What are the prevalent worries and misconceptions about dental procedures and oral health?
The picture illustrates unfavourable beliefs about dental health and the safety of seeking treatment while pregnant.
It is crucial to comprehend unfavourable ideas regarding oral health and dental treatment, with the reasons contributing to these beliefs, to develop risk-based preventative interventions and raise knowledge of oral health during pregnancy.12
Which oral hygiene guidelines should pregnant AFAB follow?
- Maintain regular dental and oral hygiene care
- Due to the direct correlation between hormonal changes during pregnancy and the development of gingival diseases and plaque accumulation, a complete oral examination before conception achieves optimal oral hygiene and develops the habit of maintaining it
- Using toothbrushes and dental floss at least twice daily is recommended for effective dental care
- Mouthwashes or warm, salted water gargling is required. Gum sensitivity decreases and relaxes with warm, salty water2
Summary
Birthing parents have pregnancy gingivitis marked by gum irritation and inflammation. Hormonal changes and an increase in progesterone levels, which make gums more susceptible to plaque and germs, are the primary cause of this illness. Preterm birth, low birth weight, and preeclampsia can result from its impact on overall health. Pregnancy gingivitis must be detected and treated to guarantee a positive experience. Preventive dental care, routine examinations, and honest dialogue with medical professionals all help to ensure a successful outcome for the birthing parent and her child.
References
- Wu M, Chen SW, Jiang SY. Relationship between gingival inflammation and pregnancy. Mediators Inflamm [Internet]. 2015 [cited 2024 Jan 15];2015:623427. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385665/
- Yenen Z, Atacag T. Oral care in pregnancy - PMC [Internet]. PubMed Central (PMC). 2019 [cited 2024 Jan 15]. Available from: https://cms.galenos.com.tr/Uploads/Article_20516/JTGGA-20-264-En.pdf
- Ojanotko‐Harri AO, Harri M ‐P., Hurttia HM, Sewoón LA. Altered tissue metabolism of progesterone in pregnancy gingivitis and granuloma. J Clinic Periodontology [Internet]. 1991 Apr [cited 2024 Jan 15];18(4):262–6. Available from: https://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.1991.tb00425.x
- Vigarios E, Maret D. Pregnancy gingivitis | QJM: An International Journal of Medicine | Oxford Academic [Internet]. OUP Academic. Oxford University Press; 2020 [cited 2024 Jan 16]. Available from: https://academic.oup.com/qjmed/article/113/10/760/5740006
- Gare J, Kanoute A, Orsini G, Gonçalves LS, Ali Alshehri F, Bourgeois D, et al. Prevalence, severity of extension, and risk factors of gingivitis in a 3-month pregnant population: a multicenter cross-sectional study. Journal of Clinical Medicine [Internet]. 2023 Jan [cited 2024 Jan 16];12(9):3349. Available from: https://www.mdpi.com/2077-0383/12/9/3349
- Patil SR. Oral changes in pregnant and nonpregnant women: A case-control study. Journal of Orofacial Sciences [Internet]. 2013 Dec [cited 2024 Jan 16];5(2):118. Available from: https://journals.lww.com/joro/fulltext/2013/05020/oral_changes_in_pregnant_and_nonpregnant_women__a.10.aspx
- Nannan M, Xiaoping L, Ying J. Periodontal disease in pregnancy and adverse pregnancy outcomes: Progress in related mechanisms and management strategies. Front Med (Lausanne) [Internet]. 2022 Oct 25 [cited 2024 Jan 16];9:963956. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640773/
- VT H, T M, T S, Nisha V A, A A. Dental considerations in pregnancy-a critical review on oral care. J Clin Diagn Res [Internet]. 2013 May [cited 2024 Jan 16];7(5):948–53. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681080/
- Oral health during pregnancy. The Journal of American Dental Association. 2011 May;[cited 2024 Jan 16]; VOLUME 142, ISSUE 5, P574,. Available from: https://jada.ada.org/article/S0002-8177(14)62017-1/fulltext#articleInformation
- Wrzosek T, Einarson A. Dental care during pregnancy. Can Fam Physician [Internet]. 2009 Jun [cited 2024 Jan 16];55(6):598–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694079/
- Erchick DJ, Rai B, Agrawal NK, Khatry SK, Katz J, LeClerq SC, et al. Oral hygiene, the prevalence of gingivitis, and associated risk factors among pregnant women in Sarlahi District, Nepal. BMC Oral Health [Internet]. 2019 Jan 5 [cited 2024 Jan 17];19(1):2. Available from: https://doi.org/10.1186/s12903-018-0681-5
- Kamalabadi YM, Campbell MK, Zitoun NM, Jessani A. Unfavourable beliefs about oral health and safety of dental care during pregnancy: a systematic review. BMC Oral Health [Internet]. 2023 Oct 15 [cited 2024 Jan 17];23(1):762. Available from: https://doi.org/10.1186/s12903-023-03439-4

