Berry Bright: Unveiling Raspberry's Vision-Boosting Powers

  • Jialu Li Master of Science in Language Sciences (Neuroscience) UCL

Are you seeking a natural way to boost your eye health? Look no further than the remarkable benefits of raspberry antioxidants. These tiny yet powerful fruits hold the key to enhancing your vision and overall eye wellness. Through their potent antioxidant properties, raspberries offer a promising solution for maintaining optimal eye health.

Berry-flavoured popsicles on a marble counter. Sprinkled with raspberries. By Daniel Oberg.1

Introduction

Raspberries, renowned for their vibrant colour and delectable taste, contain high levels of antioxidants.2 Antioxidants are compounds that help prevent or slow down damage to cells caused by free radicals.3 Free radicals are unstable molecules produced naturally in the body during metabolism and can also come from external sources like exposure to tobacco smoke, pollution, UV radiation, and certain chemicals. When free radicals accumulate, they can cause oxidative stress, damaging cells, proteins, and DNA, which may contribute to various diseases and aging.3 These antioxidants play a crucial role in protecting the eyes from oxidative stress caused by free radicals, thereby reducing the risk of age-related macular degeneration (AMD) and cataracts. By incorporating raspberries into your diet, whether fresh or frozen, you can fortify your eyes against potential damage and support long-term eye health.

Delve deeper into the world of raspberry antioxidants and discover the multitude of benefits they offer for your vision and eye health. Uncover how these potent compounds work synergistically to safeguard your eyes and learn practical tips on incorporating raspberries into your daily routine. Your journey to healthier eyes starts here!

Raspberries boast a rich array of antioxidants, each contributing distinctively to promoting eye health. These include:4

  • Vitamin C
  • Vitamin E
  • Vitamin K
  • Anthocyanin
  • α- and β- Carotene
  • Ellagitannins
  • Lutein
  • Zeaxanthin

Antioxidant benefits on eye health

Vitamin C

As a powerful antioxidant, vitamin C is crucial for maintaining the health of ocular tissues. It aids in collagen synthesis in the cornea and blood vessels of the eye, helping to strengthen and maintain their integrity.5 By reducing oxidative stress and inflammation in the eye, vitamin C may contribute to a lower risk of age-related eye diseases.

Vitamin E

Vitamin E, specifically α-tocopherol, plays a crucial role in promoting eye health primarily through its antioxidant properties.5 As a potent antioxidant, α-tocopherol safeguards cell membranes, particularly those in the retina, from oxidative damage caused by free radicals. This protection is vital given the high concentration of fatty acids in the retina, which are highly susceptible to oxidation. Although α-tocopherol loses its antioxidant capacity upon neutralizing a free radical, it can be regenerated by other antioxidants like vitamin C, reinforcing its protective role.5 Beyond its antioxidant function, α-tocopherol exhibits beneficial effects on immune and inflammatory cell molecules and enzymes, potentially contributing to the maintenance of ocular health. Additionally, its ability to inhibit platelet aggregation and improve vasodilation may aid in supporting proper blood flow to the eyes, further enhancing their overall well-being. These multifaceted functions highlight the significance of vitamin E, particularly α-tocopherol, in preserving ocular wellness.

Vitamin K

Vitamin K has recently emerged as a significant factor in promoting eye health beyond its well-known role in blood clotting. Studies suggest its importance in regulating intraocular pressure and reducing the risk of cataract surgery, particularly with higher dietary intake of vitamin K1. In addition to its conventional functions, vitamin K plays a crucial role in maintaining ocular tissue health, controlling cell processes, and influencing signalling pathways within the eye.6 Moreover, newer aspects of vitamin K, such as its antioxidant properties and impact on nuclear hormone receptors, are under investigation for their potential benefits in eye health. Severe vitamin K deficiency has been linked not only to bleeding complications but also to vision problems, emphasizing its broader relevance in supporting optimal eye function and health. Understanding the precise benefits and potential therapeutic applications of vitamin K for eye health remains an area of ongoing exploration.

Anthocyanins

These flavonoids have potent antioxidant and anti-inflammatory properties. Cyanidin-3-glucoside (C3G), the primary anthocyanin in raspberries, exhibits remarkable potential for promoting eye health.7 Its strong antioxidative properties enable effective scavenging of reactive oxygen species (ROS). Additionally, C3G's interaction with rhodopsin, a light-sensitive protein in the retina, supports the regeneration of rhodopsin following light exposure, potentially contributing to improved visual function.7 Clinical studies have suggested that anthocyanins like C3G can enhance focusing ability, reduce eye fatigue, improve contrast sensitivity, and enhance tear fluid quality. As C3G predominates in raspberries, its diverse beneficial effects hold promise in supporting optimal eye health, offering a natural approach to maintaining visual clarity and reducing eye discomfort.

α- and β-Carotene

These are precursors to vitamin A, thus holding paramount importance in supporting and maintaining optimal eye health.8 As potent antioxidants, these carotenoids play a crucial role in safeguarding the eye from oxidative stress caused by free radicals. Once converted to vitamin A in the body, they contribute significantly to the health of the retina and the maintenance of vision in low-light conditions. Specifically, beta-carotene aids in the synthesis of rhodopsin, a pigment essential for night vision, enabling the eyes to adjust to varying light intensities.9 Moreover, they help protect the eye's surface tissues and cornea, acting as a shield against harmful ultraviolet (UV) rays and reducing the risk of eye disorders such as macular degeneration and cataracts.

Ellagitannins

Ellagitannins possess strong antioxidant effects, scavenging free radicals and reactive oxygen species that contribute to oxidative stress. They have also shown promise in inhibiting inflammatory signalling pathways, including NF-κB and MAPK pathways, implicated in triggering and sustaining inflammation in the eye.10 By disrupting these pathways, ellagitannins mitigate the production of pro-inflammatory molecules, thereby exerting a direct anti-inflammatory effect on safeguarding the delicate structures of the eye, including the cornea, lens, and retina.

Lutein and zeaxanthin

Lutein and zeaxanthin, two essential antioxidants in the human macula, offer significant advantages in preserving and enhancing eye health. These compounds contribute to reducing discomfort associated with glare, improving photostress recovery time, and enhancing various aspects of visual function.11 By filtering blue light in the range of 400–500 nm, lutein and zeaxanthin diminish chromatic aberration, subsequently enhancing visual acuity and contrast sensitivity.12 Moreover, they alleviate discomfort glare, which encompasses photophobia experienced in intense light environments, and effectively mitigate disability glare caused by decreased visual acuity due to scattered light in bright settings. Studies suggest that these antioxidants, concentrated in the macula, act as an integrated filter, specifically targeting short-wavelength light to significantly reduce photophobia.9 Photostress recovery, indicative of the time needed for photopigments to regenerate after exposure to bright light, is notably improved with lutein and zeaxanthin supplementation.13 These findings underline the crucial role of lutein and zeaxanthin in mitigating discomfort associated with various lighting conditions, enhancing visual performance, and fortifying overall eye health.

These antioxidants collectively contribute to reducing inflammation, protecting against oxidative damage, and supporting overall eye health by targeting specific structures within the eye, including the cornea, lens, retina, and macula. Incorporating raspberries, rich in these antioxidants, into the diet can aid in providing the necessary compounds to support eye health and reduce the risk of eye-related conditions.

Antioxidants: insights from raspberry studies

Research into the impact of raspberry antioxidants on eye health has shown promising results, affirming the potential benefits of these compounds. A study by Stringham and Hammond (2017) investigated the effects of dietary supplementation with lutein and zeaxanthin on macular pigment optical density (MPOD) and visual performance.14 Their findings suggested that increased intake of these antioxidants led to improvements in MPOD levels and enhanced contrast sensitivity, indicating a positive influence on maintaining macular health and visual function. Moreover, a meta-analysis conducted by Banerjee et al. (2021) examined the association between dietary intake of antioxidants, including those present in raspberries, and the risk of age-related macular degeneration (AMD).15 The analysis revealed a significant inverse relationship, indicating that a higher intake of antioxidants was associated with a reduced risk of developing AMD, underscoring the potential protective effects of these compounds against age-related eye conditions. These studies collectively highlight the promising role of raspberry antioxidants in supporting eye health and emphasize their potential significance in reducing the risk of ocular diseases.14,15

How can they be incorporated into our daily diet?

Incorporating raspberries into daily meals and snacks offers a delightful and nutritious way to boost antioxidant intake for optimal health. Around 20 fresh berries contribute to fulfilling one portion of your recommended daily intake of fruits and vegetables. Practical tips for enjoying raspberries include adding them to breakfast staples like oatmeal, yoghurt, or whole-grain cereals for a burst of flavour and antioxidants. They can also serve as a convenient snack by themselves or paired with nuts for a satisfying and healthy treat between meals. For those seeking diverse culinary adventures, raspberries can elevate salads with their sweetness or be blended into refreshing smoothies for a nutrient-packed beverage. Moreover, incorporating raspberries into recipes such as fruit salads, homemade granola bars, or whole-grain muffins not only enhances taste but also maximizes antioxidant content. Combining raspberries with other vibrant fruits like blueberries or blackberries creates antioxidant-rich combinations ideal for desserts, snacks, or even as toppings for pancakes or waffles. These versatile and delicious options make it easy to infuse the diet with the powerful antioxidants present in raspberries, promoting overall health and well-being.

Nutritious Raspberry Recipes include:

Summary 

Incorporating raspberry antioxidants into your diet can significantly bolster eye health and overall wellness. These vibrant fruits, packed with potent antioxidants like vitamins C, E, K, lutein, zeaxanthin, and anthocyanins, serve as natural defenders against oxidative stress, a key factor in age-related eye conditions like macular degeneration and cataracts. The diverse range of antioxidants in raspberries plays distinct roles in preserving ocular tissues, reducing inflammation, and enhancing visual performance. Studies affirm the positive impact of raspberry antioxidants on eye health, so incorporating raspberries into your diet, whether as a refreshing snack, in breakfast meals, or in delectable recipes—provides a simple and delicious way to boost antioxidant intake, fortify eye health, and reduce the risk of eye-related ailments. Happy munching!

References 

  1. Unsplash. Photo by daniel öberg on unsplash [Internet]. 2017 [cited 2023 Dec 8]. Available from: https://unsplash.com/photos/strawberry-popsicles-3sl9_ubYIno
  2. Skrovankova S, Sumczynski D, Mlcek J, Jurikova T, Sochor J. Bioactive compounds and antioxidant activity in different types of berries. Int J Mol Sci [Internet]. 2015 Oct 16 [cited 2023 Dec 9];16(10):24673–706. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632771/
  3. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev [Internet]. 2010 [cited 2023 Dec 9];4(8):118–26. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
  4. Fooddata central. Raspberries, raw. US Department of Agriculture.  [Internet] 2018 [cited 2023 Dec 9]. Available from: https://fdc.nal.usda.gov/fdc-app.html#/food-details/167755/nutrients
  5. Rasmussen HM, Johnson EJ. Nutrients for the aging eye. Clin Interv Aging [Internet]. 2013 [cited 2023 Dec 9];8:741–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693724/ 
  6. Mong MA. Vitamin k and the visual system—a narrative review. Nutrients [Internet]. 2023 Apr 18 [cited 2023 Dec 9];15(8):1948. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143727/ 
  7. Lin Y, Li C, Shao P, Jiang L, Chen B, Farag MA. Enzymatic acylation of cyanidin-3-O-glucoside in raspberry anthocyanins for intelligent packaging: Improvement of stability, lipophilicity and functional properties. Current Research in Food Science [Internet]. 2022 Jan 1 [cited 2023 Dec 9];5:2219–27. Available from: https://www.sciencedirect.com/science/article/pii/S2665927122002118 
  8. Kaulmann A, Bohn T. Carotenoids, inflammation, and oxihttps://pubmed.ncbi.nlm.nih.gov/22229937/#:~:text=Thus%2C%20ellagitannins%20contribute%20significantly%20to,more%20relevant%20for%20food%20applications. dative stress--implications of cellular signaling pathways and relation to chronic disease prevention. Nutr Res. 2014 Nov;34(11):907–29. Available at: https://pubmed.ncbi.nlm.nih.gov/25134454/ 
  9. Johra FT, Bepari AK, Bristy AT, Reza HM. A mechanistic review of β-carotene, lutein, and zeaxanthin in eye health and disease. Antioxidants (Basel) [Internet]. 2020 Oct 26 [cited 2023 Dec 9];9(11):1046. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692753/ 
  10. Kähkönen M, Kylli P, Ollilainen V, Salminen JP, Heinonen M. Antioxidant activity of isolated ellagitannins from red raspberries and cloudberries. J Agric Food Chem. 2012 Feb 8;60(5):1167–74. Available at: 
  11. Kizawa Y, Sekikawa T, Kageyama M, Tomobe H, Kobashi R, Yamada T. Effects of anthocyanin, astaxanthin, and lutein on eye functions: a randomized, double-blind, placebo-controlled study. J Clin Biochem Nutr [Internet]. 2021 Jul [cited 2023 Dec 9];69(1):77–90. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325772/ 
  12. Lima VC, Rosen RB, Farah M. Macular pigment in retinal health and disease. Int J Retina Vitreous [Internet]. 2016 Aug 15 [cited 2023 Dec 9];2:19. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088450/ 
  13. Buscemi S, Corleo D, Di Pace F, Petroni ML, Satriano A, Marchesini G. The effect of lutein on eye and extra-eye health. Nutrients [Internet]. 2018 Sep 18 [cited 2023 Dec 9];10(9):1321. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164534/
  14. Stringham JM, O’Brien KJ, Stringham NT. Contrast sensitivity and lateral inhibition are enhanced with macular carotenoid supplementation. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2291–5. Available at: https://pubmed.ncbi.nlm.nih.gov/28431432/ 
  15. Banerjee M, Chawla R, Kumar A. Antioxidant supplements in age-related macular degeneration: are they actually beneficial? Ther Adv Ophthalmol [Internet]. 2021 Aug 27 [cited 2023 Dec 9];13:25158414211030418. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404659/ 
This content is purely informational and isn’t medical guidance. It shouldn’t replace professional medical counsel. Always consult your physician regarding treatment risks and benefits. See our editorial standards for more details.

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