What Is Factor XII Deficiency?

  • Ayesha Jamil  Bachelors of Biomedical Sciences with Honors - University of Nottingham, Malaysia


Factor XII (Hageman Factor) deficiency is a very rare genetic disorder that involves the blood's ability to clot properly. It can sound complicated, but understanding the role Factor XII plays and its impact on the coagulation cascade (the process of forming a clot) is key to understanding this genetic disorder.

The role of factor XII in the coagulation cascade

To appreciate the importance of Factor XII deficiency, it's helpful to grasp the broader picture of blood clotting. When you cut yourself, your body swiftly initiates a series of reactions to prevent excessive bleeding. This sequence of events is known as the coagulation cascade, where various proteins and factors collaborate in a carefully choreographed dance.

Factor XII, one of these essential factors, is like a conductor orchestrating this dance. Its primary role is to activate other proteins that lead to the formation of fibrin, a mesh-like structure that helps seal the wound and stop bleeding. This cascade ensures that a simple paper cut doesn't turn into a more serious problem.

Imagine Factor XII as the starter pistol at the beginning of a race. It sets off a chain reaction that eventually culminates in the formation of a stable clot, safeguarding us from excessive blood loss. However, when Factor XII is deficient, this chain reaction doesn't unfold as smoothly, potentially leading to prolonged bleeding or, paradoxically, even excessive clotting in some cases.1


Now that we grasp the pivotal role of Factor XII in the blood clotting process let's journey into understanding what causes Factor XII deficiency. At its core, this condition is predominantly a genetic one. Our genes, the DNA instructions that shape us, can sometimes carry alterations that impact how our body produces and uses Factor XII.

Genetic inheritance patterns

Autosomal recessive inheritance

Factor XII deficiency is typically inherited in an autosomal recessive manner. This means that an individual must inherit two defective copies of the F12 gene - one from each parent - to develop the deficiency. Parents who each carry one faulty gene are usually unaffected, but their offspring have a one-in-four chance of inheriting both defective genes and thus experiencing the deficiency.1

Mutations in the F12 gene

Effect on factor XII production or function

It's within the F12 gene that the blueprint for producing Factor XII lies. Mutations or changes in this gene can disrupt the normal functioning of Factor XII, resulting in reduced levels or impaired activity of the protein. Think of it like a typographical error in a recipe that changes the taste of a dish – these mutations can alter the structure and function of Factor XII, impacting the coagulation process.

While genetics play a significant role in Factor XII deficiency, it's important to note that not everyone with a genetic mutation will experience symptoms. Some individuals might carry the mutation without ever knowing, as their bodies can compensate for the deficiency to a certain extent.1


Although the condition is often asymptomatic, meaning there are no visible symptoms, there are other indicators, including:

  • Prolonged bleeding after injuries or surgeries
  • Epistaxis (nosebleeds)
  • Easy bruising
  • Blood clots (rare)


Routine coagulation tests - activated partial thromboplastin time (aPTT)

One of the initial steps in diagnosis involves routine coagulation tests. One such test is the activated partial thromboplastin time (aPTT) test. This test measures the time it takes for blood to clot and can indicate abnormalities in the coagulation process. If the aPTT is prolonged, it might suggest a potential deficiency in one of the factors involved, including Factor XII.3

Mixing studies - distinguishing between factor deficiency and inhibitor presence

Mixing studies can be employed to refine the diagnosis further. These studies involve mixing the patient's blood with normal blood plasma. If the clotting time improves after mixing, it suggests that a factor deficiency is contributing to the prolonged clotting time. This helps differentiate between a deficiency in a specific factor like Factor XII and the presence of inhibitors that could also prolong clotting time.4

Genetic testing - identifying specific mutations in the F12 gene

In some cases, genetic testing can provide conclusive evidence of Factor XII deficiency. By examining the F12 gene, experts can identify specific mutations that underlie the condition. This not only aids in confirming the diagnosis but also offers insight into the potential inheritance patterns that might affect other family members.

Differential diagnosis

This term might sound complex, but it simply refers to the process of differentiating one condition from others that share similar symptoms. This step ensures that the correct diagnosis is made, leading to appropriate treatment and management decisions.

Differentiating from other bleeding disorders - haemophilia A and B and von Willebrand disease

Factor XII deficiency can sometimes exhibit symptoms similar to other bleeding disorders, such as haemophilia A and B or von Willebrand disease. These conditions also affect the clotting process and can lead to prolonged bleeding after injuries or surgeries. However, the underlying mechanisms and specific factors involved differ.

By carefully considering the patient's medical history, symptoms, and the results of diagnostic tests, medical professionals can pinpoint the specific disorder causing the symptoms. This precision is crucial in tailoring treatment plans to suit the individual's needs.5

Differentiating from other thrombotic disorders - deep vein thrombosis and pulmonary embolism

Interestingly, while Factor XII deficiency is primarily associated with bleeding tendencies, there have been occasional reports of thrombotic events (clot formation) in individuals with this deficiency. This can add a layer of complexity to diagnosis, as thrombotic disorders like deep vein thrombosis or pulmonary embolism also involve abnormal clotting.6

Here, the distinctive presentation and underlying mechanisms of Factor XII deficiency come into play. The rarity of thrombotic events in this context often helps to differentiate it from primary thrombotic disorders.


Treatment for bleeding episodes

Local measures (pressure, sutures)

For individuals with Factor XII deficiency, the most common concern is bleeding tendencies. Prolonged bleeding after injuries, nosebleeds, and easy bruising can become distressing. The first step in managing these episodes is adopting local measures. Applying pressure to wounds, using sutures (stitches), or using appropriate dressings can help staunch bleeding.

Replacement therapy (fresh frozen plasma, factor concentrate)

In more severe cases, replacement therapy might be necessary. This involves providing the missing or deficient clotting factor. Fresh frozen plasma or specific factor concentrates can be administered to aid the coagulation process. These therapies can effectively counteract bleeding tendencies and enable individuals to lead active lives.7

Prophylactic treatment (rarely necessary)

In some instances, prophylactic measures might be considered, particularly before surgical procedures or other activities that carry a higher risk of bleeding. This involves administering clotting factor replacements in advance to prevent excessive bleeding. However, it's important to note that not all individuals with Factor XII deficiency require prophylactic treatment, as the severity of the deficiency can vary.

Thrombotic event management - anticoagulation therapy (if applicable)

While Factor XII deficiency is primarily associated with bleeding tendencies, the potential for thrombotic events exists, albeit rarely. In cases where thrombosis is a concern, anticoagulation therapy might be employed to reduce the risk of clot formation. However, it's crucial to weigh the benefits and risks carefully, as anticoagulation can also predispose individuals to bleeding complications.

Genetic counselling and family planning

Understanding the genetic basis of Factor XII deficiency is pivotal for those planning families. Genetic counselling can provide valuable insights into the risk of passing on the condition to offspring. This information empowers individuals and families to make informed decisions and consider options to ensure the health of future generations.


Challenges in diagnosis due to mild symptoms

One significant challenge lies in the diagnosis itself. Factor XII deficiency often manifests with mild or even absent symptoms, making it challenging to identify without specific testing. This can lead to misdiagnosis or delayed diagnosis, potentially hindering timely intervention.

Potential for misdiagnosis or unnecessary treatments

Due to the overlapping symptoms with other bleeding disorders, there's a risk of misdiagnosis. Mistaking Factor XII deficiency for conditions like Von Willebrand disease or other clotting factor deficiencies could lead to inappropriate treatments and unnecessary worry.

Emotional and psychological impact on patients

Beyond the physical aspects, Factor XII deficiency can have emotional and psychological ramifications. Living with a chronic condition, even one with relatively mild symptoms, can pose emotional challenges. Coping with the uncertainty of potential bleeding or clotting events may require individuals to develop strong support networks and coping strategies.

Research and future directions

Further understanding of the role of Factor XII in coagulation

Researchers are delving deeper into the intricate role of Factor XII in the coagulation cascade. Despite being seen as a minor player compared to other clotting factors, emerging insights suggest that Factor XII may have a more complex role, extending beyond its conventional function. These discoveries could lead to a more nuanced understanding of clotting disorders and novel therapeutic approaches.

Developing targeted therapies for Factor XII deficiency

The field of medical research is vibrant with the pursuit of targeted therapies for Factor XII deficiency. Scientists are investigating ways to manipulate the coagulation process in individuals with this deficiency, potentially offering treatments that are more specific and efficient. Such therapies could revolutionise the management of Factor XII deficiency, enhancing both the quality of life and the overall health of affected individuals.

Investigating the relationship between Factor XII and thrombosis

The relationship between Factor XII deficiency and thrombosis continues to intrigue researchers. While generally associated with bleeding tendencies, the sporadic occurrence of thrombotic events raises questions about the interplay between clotting and bleeding factors. Understanding this dynamic might unlock insights into broader mechanisms of coagulation and provide new avenues for preventing and managing both bleeding and clotting disorders.


Factor XII, a crucial participant in the coagulation cascade, orchestrates the process of blood clotting. Its deficiency, often inherited in an autosomal recessive manner, can lead to bleeding tendencies or, in rare cases, thrombotic events. Diagnosis, though challenging due to mild symptoms, involves tests like aPTT, mixing studies, and genetic testing, allowing accurate identification.

Differential diagnosis sets Factor XII deficiency apart from other conditions with similar symptoms. Distinctive presentations and underlying mechanisms aid medical professionals in making accurate determinations. Management strategies focus on addressing bleeding episodes through local measures and replacement therapy. Prophylactic measures and anticoagulation therapy might be considered to navigate bleeding and clotting risks, respectively.

Complications, including challenges in diagnosis, potential for misdiagnosis, and emotional impact, underscore the multifaceted nature of Factor XII deficiency. By acknowledging these facets, individuals can be better prepared for their journey. Research strides towards a comprehensive understanding of Factor XII's role, opening avenues for targeted therapies and unravelling the complex relationship with thrombosis.

Factor XII deficiency, while intricate, becomes comprehensible through careful explanation and guidance. Armed with this knowledge, individuals, families, and healthcare providers can navigate the challenges posed by this condition, ensuring that a brighter, healthier future remains within reach.


  1. Stavrou E, Schmaier AH. Factor xii: what does it contribute to our understanding of the physiology and pathophysiology of hemostasis & thrombosis? Thromb Res [Internet]. 2010 Mar [cited 2023 Aug 18];125(3):210–5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851158/
  2. Ratnoff OD, Colopy JE. A familial hemorrhagic trait associated with a deficiency of a clot-promoting fraction of plasma 1. J Clin Invest [Internet]. 1955 Apr [cited 2023 Aug 18];34(4):602–13. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC438666/
  3. Rountree KM, Yaker Z, Lopez PP. Partial thromboplastin time. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Aug 18]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK507772/
  4. Liu C, Ling L, Huang X, Mi J, Liao J, Jia J, et al. Evaluation of activated partial thromboplastin time mixing studies using several methods. Archives of Pathology & Laboratory Medicine [Internet]. 2022 Nov 1 [cited 2023 Aug 18];146(11):1387–94. Available from: https://meridian.allenpress.com/aplm/article/146/11/1387/478886/Evaluation-of-Activated-Partial-Thromboplastin
  5. Sharma P. Hemophilia and von willebrand disease: factor viii and von willebrand factor. Indian J Med Res [Internet]. 2019 May [cited 2023 Aug 18];149(5):685–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702706/
  6. Roberts LN, Arya R. Deep vein thrombosis and pulmonary embolism: diagnosis, treatment and prevention. Clin Med (Lond) [Internet]. 2011 Oct [cited 2023 Aug 18];11(5):465–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954241/
  7. Al-Ansari RY, Al-Yami F, Almulhim G, Woodman A. Hereditary factor XII deficiency in an adult patient: A case report. SAGE Open Medical Case Reports [Internet]. 2022 Jan [cited 2023 Aug 18];10:2050313X2211187. Available from: http://journals.sagepub.com/doi/10.1177/2050313X221118728
This content is purely informational and isn’t medical guidance. It shouldn’t replace professional medical counsel. Always consult your physician regarding treatment risks and benefits. See our editorial standards for more details.

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Ayesha Jamil

Bachelors of Biomedical Sciences with Honors - University of Nottingham, Malaysia

Ayesha is a passionate graduate who is highly motivated to do her best in all that she tries. functioning in a multicultural university society on campus, she has developed many skills including communication, leadership skills, and developed a strong work ethic to name a few while in university.

She was the course representative for all three of her academic years working closely with the teaching and management staff to ensure the needs and voices of her fellow students were heard as well as the implementation of any new protocol for the students that may have been introduced for them.

She has also undertaken many key roles as well as been a part of the volunteering fellows. She has taken another step towards the future by undertaking an internship with Klarity as a writer for medical articles.

my.klarity.health presents all health information in line with our terms and conditions. It is essential to understand that the medical information available on our platform is not intended to substitute the relationship between a patient and their physician or doctor, as well as any medical guidance they offer. Always consult with a healthcare professional before making any decisions based on the information found on our website.
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