What Is Visceral Hypersensitivity?

  • Baraneethan Gajendrakumar Doctor of Medicine - MD, Medicine, Dnipropetrovsk University of Traditional and Non - traditional medicine

Understanding visceral hypersensitivity: Causes, symptoms, and management

If you've ever experienced heightened sensitivity or discomfort in your abdomen, you might be curious about visceral hypersensitivity. In this comprehensive article, we'll delve into what visceral hypersensitivity is, its potential causes, common symptoms, and effective management strategies.1-3,5,6 By the end, you'll have a clearer understanding of this condition and how it can be managed to improve quality of life.


Visceral hypersensitivity is a medical term that describes an enhanced perception of pain or discomfort originating from the internal organs, primarily the digestive system.1 This means that individuals with this condition tend to feel pain or discomfort more intensely than others in response to stimuli that typically wouldn't cause such sensations. This heightened sensitivity can occur in various parts of the body, but it most commonly affects the abdominal region.

Common causes of visceral hypersensitivity 

Understanding the potential causes of visceral hypersensitivity is crucial for effectively managing the condition. While the exact cause can vary from person to person, several factors have been associated with its development:

  • Gastrointestinal disorders: Many individuals with gastrointestinal conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and functional dyspepsia experience visceral hypersensitivity.1 In these cases, chronic inflammation and altered nerve signalling in the gut can contribute to heightened sensitivity
  • Stress and anxiety: Psychological factors like chronic stress and anxiety can exacerbate visceral hypersensitivity. The brain-gut connection plays a significant role as heightened emotional states can trigger  sensitivity in the digestive tract
  • Infections: Certain infections can lead to visceral hypersensitivity, especially if they cause inflammation or damage to the gastrointestinal lining. Post-infectious IBS is an example of a condition that can result from such infections
  • Genetics: Research suggests that genetics may also play a role in predisposing some individuals to visceral hypersensitivity. Certain genetic variations can influence how the nervous system perceives and processes pain signals from the organs
  • Dietary factors: Some foods can trigger or exacerbate symptoms in individuals with visceral hypersensitivity. High-FODMAP foods, for instance, are known to cause digestive discomfort in susceptible individuals.2
  • Medications: Certain medications, such as non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics, can irritate the gastrointestinal tract and contribute to hypersensitivity

Common symptoms 

Visceral hypersensitivity can manifest in various ways, and the symptoms can range from mild to severe. Common symptoms include:

  • Abdominal pain: Abdominal pain is the hallmark symptom of visceral hypersensitivity. The pain can vary in intensity, duration, and location but often occurs in the lower abdomen3
  • Bloating: Many individuals with visceral hypersensitivity experience abdominal bloating, which can be uncomfortable and distressing3
  • Altered bowel habits: Changes in bowel habits, such as diarrhoea, constipation, or alternating between the two, are common in individuals with this condition.3
  • Nausea: Visceral hypersensitivity can lead to feelings of nausea, especially during or after meals3
  • Discomfort during eating: Some people may feel discomfort or pain while eating, which can limit their enjoyment of food.3
  • Increased sensitivity to food: Certain foods can trigger or worsen symptoms in those with visceral hypersensitivity3
  • Stress and anxiety: Psychological symptoms like anxiety and depression often co-occur with this condition, as the gut-brain connection plays a significant role.3

In the following sections, we'll explore strategies for diagnosing visceral hypersensitivity, discuss potential complications, and provide practical tips for managing and improving the quality of life for those affected by this condition.

Diagnosing visceral hypersensitivity 

Diagnosing visceral hypersensitivity can be challenging as it primarily relies on clinical evaluation and the patient's description of their symptoms. To confirm the diagnosis and rule out other conditions, healthcare providers may employ the following approaches:

  • Medical history: The doctor will take a detailed medical history, including information about your symptoms, their onset, and any triggering factors like stress or dietary habits.
  • Physical examination: A thorough physical examination, with a focus on the abdomen, can help identify any signs of tenderness or abdominal distention.
  • Imaging studies: In some cases, imaging tests like abdominal ultrasound, CT scans, or MRI may be ordered to rule out structural abnormalities.
  • Laboratory tests: Blood tests may be conducted to check for markers of inflammation and rule out other conditions like coeliac disease or inflammatory bowel disease.4
  • Endoscopy: A procedure like upper endoscopy or colonoscopy may be recommended to visualize the gastrointestinal tract and assess its condition.
  • Visceral sensitivity testing: This specialized test measures an individual's response to distension of the gastrointestinal organs and can help confirm visceral hypersensitivity.

Management and treatment

While visceral hypersensitivity can be challenging to treat definitively, several strategies can help manage and alleviate symptoms:

  • Dietary modifications: Identifying and avoiding trigger foods can significantly reduce symptoms. Working with a registered dietitian can be beneficial in developing a personalized diet plan.5
  • Stress management: Learning stress-reduction techniques such as mindfulness, meditation, and deep breathing exercises can help calm the gut-brain connection and lessen symptom severity.5
  • Medications: Depending on the severity of symptoms, healthcare providers may recommend medications like antispasmodics, antidepressants, or antianxiety drugs to manage pain and discomfort.5
  • Therapies: Psychological therapies like cognitive-behavioural therapy (CBT) can help individuals cope with stress and anxiety, which can, in turn, improve gut symptoms.5
  • Probiotics: Some individuals find relief from symptoms by incorporating probiotics into their daily routine. These can help balance gut bacteria.5
  • Lifestyle modifications: Regular exercise, adequate sleep, and avoiding tobacco and excessive alcohol consumption can contribute to symptom improvement.5
  • Support groups: Joining support groups or seeking therapy can provide emotional support and coping strategies for dealing with visceral hypersensitivity.5

Complications and when to seek medical attention

Visceral hypersensitivity, if left untreated or unmanaged, can lead to complications such as reduced quality of life, where persistent symptoms can significantly impact one's daily life, work, and social activities. Additionally, visceral hypersensitivity can cause psychological distress. The emotional toll of chronic symptoms can often lead to anxiety and depression. Visceral hypersensitivity can also result inmalnutrition wheresevere symptoms can affect nutrient absorption.7 

If you or someone you know experiences severe or worsening symptoms, it's crucial to seek medical attention promptly. Additionally, if you notice unexplained weight loss, blood in the stool, or severe abdominal pain, consult a healthcare provider immediately, as these may indicate more serious underlying conditions.


Visceral hypersensitivity is a condition characterized by a heightened perception of pain and discomfort in the internal organs, primarily the digestive system. It can be triggered by various factors, including gastrointestinal disorders, stress, genetics, dietary choices, and medications.1,2, Effective management involves a combination of dietary modifications, stress management, medication, and lifestyle changes.5,6 Early diagnosis and a personalized treatment plan can significantly improve one's quality of life. 


  1. Sperber AD, Drossman DA. Irritable bowel syndrome: a global perspective. In: Irritable Bowel Syndrome: Diagnosis and Clinical Management. BC Decker; 2011. p. 3-12. Available from: https://www.annualreviews.org/doi/10.1146/annurev.med.52.1.319
  2. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology. 2004;126(3):693-702. Available from: https://www.gastrojournal.org/article/S0016-5085(03)01996-6/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
  3. Camilleri M. Visceral hypersensitivity: in irritable bowel syndrome and functional dyspepsia. Gastroenterology. 2012;142(3):808-811.
  4. Mearin F, Lacy BE. Diagnostic criteria in visceral pain: from empiricism to global consensus. Neurogastroenterology & Motility. 2017;29(1):e12947.
  5. Ford AC, Moayyedi P, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. The American Journal of Gastroenterology. 2014;109(Suppl 1):S2-S26. Available from: https://journals.lww.com/ajg/fulltext/2014/08001/american_college_of_gastroenterology_monograph_on.2.aspx
  6. Black C, Thakur RE, Houghton LA, Quigley EMM, Moayyedi P, Ford AC. ‘Efficacy of Psychological Therapies for Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis’. Gut, vol. 69, no. 8, Aug. 2020, pp. 1441–51. Available from: https://doi.org/10.1136/gutjnl-2020-321191.
  7. Drossman DA. Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology. 2016;150(6):1262-1279. Available from: https://www.gastrojournal.org/article/S0016-5085(16)00223-7/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
This content is purely informational and isn’t medical guidance. It shouldn’t replace professional medical counsel. Always consult your physician regarding treatment risks and benefits. See our editorial standards for more details.

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