Health Benefits Of Cloves

What are cloves?

Before we had modern dentistry, we had cloves!  

Cloves are the clove tree's dry, unopened flower buds (Syzygium aromaticum). They are native to the Maluku islands in Indonesia “Native to the Maluku islands in Indonesia, Cloves are the clove tree’s dry, unopened flower buds (Syzygium aromaticum)”. However, they have been grown across the globe and are used in a wide variety of sweet and savoury dishes due to their aromatic fragrance.1

Historically, cloves have also been exploited for their medicinal properties and have been used in food preservation. Interestingly, modern chemical analysis of cloves has shown that they are much more complex than just a mere spice/flavour and can offer a range of valuable therapeutic properties, including anti-cancerous properties.2

Health benefits of cloves

Besides their delicious flavour, cloves are highly pharmacologically active, containing a range of phytochemicals (biologically active chemicals produced by plants) that can benefit humans. Cloves are rich in sesquiterpenes, hydrocarbon, monoterpenes and phenolic compounds. In clove oil, the most significant phytochemicals include eugenyl acetate, eugenol, and β-caryophyllene.2

There have been several reports documenting the pharmacological activity of eugenol, including its antioxidant, anti-depressant, antispasmodic, anti-inflammatory, analgesic, antiviral, antifungal, antiseptic and antibacterial activity against several pathogenic bacteria, including methicillin-resistant Staphylococcus epidermidis and S. aureus.2 

10 therapeutic properties of cloves are summarised below:

  • Protection against skin damage - an investigation into the effects of cloves on the skin of mice exposed to UVB (ultraviolet-B) revealed that cloves protect against skin damage from UVB, due to their ability to regulate oxidation, inflammation and energy consumption in the body.3
  • Anti-inflammatory and wound healing properties - Cloves were found to have healing properties in wound-induced mice, with results similar to that of neomycin which is currently used as an antibiotic to control inflammation and heal wounds.4
  • Analgesic properties - Clove essential oil (CEO) offers analgesic properties with the capacity to treat headaches, toothaches and joint pain. It is also used widely as an oral antiseptic.5-6
  • Improvement in  male sexual health - cloves have been documented to possess nerve-stimulating activity, which may increase sexual performance, increase sexual motivation and reduce premature ejaculations.7-8
  • Anti-depressive properties - The active phytochemical eugenol found in cloves, along with its analogues (similar chemical structure, differing in another regard), contribute to reducing Monoamine oxidase A which demonstrates anti-depressive activity.9 
  • Anti-diabetic and regulation of blood glucose - cloves have been found to suppress an increase in blood glucose in type-2 diabetic mice, indicating that it may be a helpful ingredient for patients with type 2 diabetes.10
  • Improves liver health - studies show that cloves can protect against fatty liver, dyslipidemia (imbalance of lipids) and cirrhosis (scarring of the liver from long-term damage). Cloves can inhibit cell multiplication and decrease oxidative stress, both of which may protect against liver cirrhosis.11-12
  • Promote bone health - Cloves are helpful in bone preservation, with studies showing a positive effect on bone density, bone tensile strength and bone mineral content.13
  • Reduce stomach ulcers - Cloves have been found to increase mucus production in the stomach, which offers gastroprotective properties which may prevent stomach ulcers.14
  • Anti-cancer properties -  Cloves contain eugenol, α-humulene, and β-caryophyllene, which have been found to have cytotoxic and anti-tumour activity. The anti-cancer property is mainly associated with CEO's anti-inflammatory and antioxidant properties.15

Nutritional facts

A serving size (2.1g) of cloves will provide 5.8 calories making it ideal for a low-calorie diet. A serving size will provide carbohydrates (1.4g), of which 50% is dietary fibre, making it an ideal supplement to any dish to increase the total fibre content. A serving size will also provide fats (0.3g) and protein (0.1g). Cloves are also rich in essential minerals, including manganese, calcium, iron and magnesium. Some of which are essential for the numerous therapeutic benefits mentioned above.16-17

Side effects and other concerns

The essential oil of cloves is generally considered safe for human consumption. The WHO (World Health Organisation) has established a guideline where the recommended daily intake should not exceed 2.5mg/kg of weight in humans.8,18

Summary

Cloves are an absolute powerhouse of phytochemicals that can immensely benefit human health, with benefits ranging from preventing depression to preserving and strengthening bones. Additionally, cloves have displayed anti-inflammatory, analgesic, antiviral and anti-cancerous properties. In truth, the benefits of cloves are numerous, and it would be impossible to cover them all in a single article. A fact supported by hundreds of research papers focused on the therapeutic utilisation of cloves and their essential oil. 

Practically, cloves can be used by people of all ages in their diet. Some ideas include throwing a portion in a Thai/Indian curry, using them when cooking meat/fish or using them to fragrance rice. 

References

  1. Cloves: an exotic flavor best used with a measure of restraint [Internet]. The Spruce Eats. [cited 2023 Mar 17]. Available from: https://www.thespruceeats.com/what-are-cloves-995621
  2. Batiha GES, Alkazmi LM, Wasef LG, Beshbishy AM, Nadwa EH, Rashwan EK. Syzygium aromaticum l. (Myrtaceae): traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules. 2020 Jan 30;10(2):202. 
  3. Gao X, Luo F, Zhao H. Cloves regulate na+-k+-atpase to exert antioxidant effect and inhibit uvb light-induced skin damage in mice. Oxid Med Cell Longev. 2021;2021:5197919. 
  4. Banerjee K, Madhyastha H, Sandur V R, N T M, N T, Thiagarajan P. Anti-inflammatory and wound healing potential of a clove oil emulsion. Colloids Surf B Biointerfaces. 2020 Sep;193:111102. 
  5. Soto CG, Burhanuddin. Clove oil as a fish anaesthetic for measuring length and weight of rabbitfish (Siganus lineatus). Aquaculture [Internet]. 1995 Nov [cited 2023 Mar 17];136(1–2):149–52. Available from: https://linkinghub.elsevier.com/retrieve/pii/0044848695010513
  6. Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, et al. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum l. Myrtaceae): a short review. Phytother Res. 2007 Jun;21(6):501–6. 
  7. Tajuddin  null, Ahmad S, Latif A, Qasmi IA. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (Nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (Clove) in male mice: a comparative study. BMC Complement Altern Med. 2003 Oct 20;3:6. 
  8. Cortés-Rojas DF, de Souza CRF, Oliveira WP. Clove (Syzygium aromaticum): a precious spice. Asian Pac J Trop Biomed. 2014 Feb;4(2):90–6. 
  9. Tao G, Irie Y, Li DJ, Keung WM. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorg Med Chem. 2005 Aug 1;13(15):4777–88. 
  10. Kuroda M, Mimaki Y, Ohtomo T, Yamada J, Nishiyama T, Mae T, et al. Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-Ay mice and identification of the active ingredients. J Nat Med [Internet]. 2012 Apr 1 [cited 2023 Mar 17];66(2):394–9. Available from: https://doi.org/10.1007/s11418-011-0593-z
  11. Ali S, Prasad R, Mahmood A, Routray I, Shinkafi TS, Sahin K, et al. Eugenol-rich fraction of syzygium aromaticum (Clove) reverses biochemical and histopathological changes in liver cirrhosis and inhibits hepatic cell proliferation. J Cancer Prev [Internet]. 2014 Dec [cited 2023 Mar 17];19(4):288–300. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285960/
  12. Al-Okbi SY, Mohamed DA, Hamed TE, Edris AE. Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome. J Med Food. 2014 Jul;17(7):764–71. 
  13. Karmakar S, Choudhury M, Das AS, Maiti A, Majumdar S, Mitra C. Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy. Natural Product Research [Internet]. 2012 Mar 1 [cited 2023 Mar 17];26(6):500–9. Available from: https://doi.org/10.1080/14786419.2010.511216
  14. Santin JR, Lemos M, Klein-Júnior LC, Machado ID, Costa P, de Oliveira AP, et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn-Schmied Arch Pharmacol [Internet]. 2011 Feb 1 [cited 2023 Mar 17];383(2):149–58. Available from: https://doi.org/10.1007/s00210-010-0582-x
  15. Liu H, Schmitz JC, Wei J, Cao S, Beumer JH, Strychor S, et al. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Oncol Res [Internet]. 2014 [cited 2023 Mar 17];21(5):247–59. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132639/
  16. Cloves - check your food [Internet]. [cited 2023 Mar 17]. Available from: https://www.checkyourfood.com/ingredients/ingredient/260/cloves
  17. Spices, ground, cloves nutrition facts and analysis. [Internet]. [cited 2023 Mar 17]. Available from: https://www.nutritionvalue.org/Spices%2C_ground%2C_cloves_nutritional_value.html
  18. Gülçin İ, Elmastaş M, Aboul-Enein HY. Antioxidant activity of clove oil – A powerful antioxidant source. Arabian Journal of Chemistry [Internet]. 2012 Oct [cited 2023 Mar 17];5(4):489–99. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1878535210001899
This content is purely informational and isn’t medical guidance. It shouldn’t replace professional medical counsel. Always consult your physician regarding treatment risks and benefits. See our editorial standards for more details.

Get our health newsletter

Get daily health and wellness advice from our medical team.
Your privacy is important to us. Any information you provide to this website may be placed by us on our servers. If you do not agree do not provide the information.

Leave a Reply

Your email address will not be published. Required fields are marked *

my.klarity.health presents all health information in line with our terms and conditions. It is essential to understand that the medical information available on our platform is not intended to substitute the relationship between a patient and their physician or doctor, as well as any medical guidance they offer. Always consult with a healthcare professional before making any decisions based on the information found on our website.
Klarity is a citizen-centric health data management platform that enables citizens to securely access, control and share their own health data. Klarity Health Library aims to provide clear and evidence-based health and wellness related informative articles. 
Email:
Klarity / Managed Self Ltd
Alum House
5 Alum Chine Road
Westbourne Bournemouth BH4 8DT
VAT Number: 362 5758 74
Company Number: 10696687

Phone Number:

 +44 20 3239 9818